Low prevalence of mcr-1 in Escherichia coli from food-producing animals and food products in China

Mei, Cai-Yue; Jiang, Yue; Ma, Qin-Chun; Lu, Meng-Jun; Wu, Han; Wang, Zhen-Yu; Jiao, Xinan; Wang, Jing

doi:10.1186/s12917-024-03891-6

BMC Veterinary Research

Table 1 Characteristics of mcr-1-carrying E. coli isolates in this study

From: Low prevalence of mcr-1 in Escherichia coli from food-producing animals and food products in China

Strain^a	Source	ST	Resistance genes	Colistin MIC (mg/L)	Other resistance patterns^b	mutations		mcr-1 location	plasmids replicons
Strain^a	Source	ST	Resistance genes	Colistin MIC (mg/L)	Other resistance patterns^b	gyrA	parC	mcr-1 location	plasmids replicons
YZ19MCE13	chicken meat, 2019	48	bla_{CTX−M−123}, bla_OXA−1, aph(4)-Ia, ΔaadA8, aph(3’)-IIa, aac(3)-IVa, catB3, aac(6’)Ib-cr, fosA, mcr-1, sul2, dfrA12, mph(A), arr-3	4	AMP/CFZ/CTX/GEN/CHL/NAL/CIP/FOS/SXT	S83L D87N	S80I	pYUYZMC13-MCR (IncI2, 59,874 bp)	IncI2, IncFII, IncFIB, IncY, Col156
YZ20MCE6	chicken meat, 2020	6388	bla_CTX−M−55, aadA2, aadA22, strAB, tet(A), floR, fosA, mcr-1, sul1, sul2, drfA12	4	AMP/CFZ/CTX/STR/TET/CHL/FFC/NAL/CIP/FOS/SXT	S83L D87N	S80I	pYUYZMC6-MCR (IncI2, 60,961 bp)	IncI1, IncI2, IncFII, IncFIB, p0111, Col(MG828)
SD20MCE15	chicken meat, 2020	1011	bla_TEM−1B, bla_CTX−M−55, bla_OXA−1, aadA2, aac(3)-IId, aph(3’)-Ia, strAB, tet(A), floR, catA1, catB3, oqxAB, Δaac(6’)Ib-cr, mcr-1, sul1, sul2, drfA12, mph(A), arr-3	8	AMP/CFZ/CTX/GEN/STR/TET/CHL/FFC/NAL/CIP/SXT	S83L D87N	S80I	pYUSDMC15-MCR (IncI2, 63,538 bp)	IncI2, IncFII, IncFIB
YZ19MCE34	chicken meat, 2019	10	bla_TEM−1B, aac(3)-IId, aadA1, aadA2, aph(3’)-Ia, tet(A), tet(M), cmlA1, floR, mcr-1, sul2, sul3, dfrA12, Δmef(B), lnu(F)	8	AMP/GEN/STR/TET/CHL/FFC/NAL/CIP/SXT	S83L D87N	S80I	pYUYZMC34-MCR (IncI2, 63,410 bp)	IncI1, IncI2, IncFII, IncFIB
LN19MCE7	chicken meat, 2019	155	bla_CTX−M−55, bla_CTX−M−14, aadA1, aadA2, aadA5, aac(3)-IVa, aph(4)-Ia, strAB, tet(A), cmlA1, floR, fosA, mcr-1, sul1, sul2, drfA17	16	AMP/CFZ/CTX/GEN/STR/TET/CHL/FFC/NAL/CIP/FOS/SXT	S83L D87N	S80I	pYULNMC7-MCR (IncI2, 63,612 bp)	IncI1, IncI2, IncHI2, IncFII, IncFIB, Col156
YZ19MCE28	chicken meat, 2019	101	bla_CTX−M−14, bla_OXA−1, aph(3’)-IIa, tet(A), catB3, aac(6’)Ib-cr, arr-3, mcr-1, sul1, mph(A)	8	AMP/CFZ/CTX/TET/CHL/NAL/CIP	S83L D87Y	S80I	pYUYZMC28-MCR (IncI2, 62,638 bp)	IncFII, IncFIB, IncHI2, IncI2, Col(MG828), Col156
SD20MCE26	chicken meat, 2020	3871	bla_CTX−M−55, bla_TEM−1b, bla_CTX−M−14, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aph(4)-Ia, aph(3’)-Ia, rmtB, tet(A), floR, cmlA1, oqxAB, qnrS2, fosA, mcr-1, sul1, sul2, sul3, mph(A)	8	AMP/CFZ/CTX/GEN/STR/AMI/TET/CHL/FFC/NAL/FOS/SXT	None	A56T	contig 49 (IncHI2, 101,306 bp)	IncHI2, IncX1, p0111, Col440I
YZ19PE15	pig, 2019	10	strAB, tet(A), mcr-1	8	STR/TET	None	None	pYUYZP15-MCR (IncX4, 34,541 bp)	IncX1, IncX4, IncFII, IncFIA, IncFIB(K), Col(MG828), ColE10
AH20PE7	pig, 2020	101	bla_TEM−1b, aadA1, aadA2, ΔaadA22, aac(3)-IId, aph(3’)-Ia, tet(M), tet(A), floR, cmlA1, oqxAB, mcr-1, sul2, sul3, dfrA12, mph(A), Δmef(B), erm(42)	4	AMP/GEN/STR/TET/CHL/FFC/NAL/CIP/SXT	S83L D87N	S80I	pYUAHP7-MCR (IncX4, 36,021 bp)	IncX1, IncX4, F33:A1:B1, p0111
AH20CE39	chicken, 2020	156	bla_CTX−M−55, bla_OXA−10, bla_TEM−1B, aadA1, ΔaadA22, aph(3’)-Ia, aph(3’)-IIa, aph(4)-Ia, aac(3)-IVa, strAB, tet(A), cmlA1, floR, qnrS1, fosA, mcr-1, sul1, sul2, dfrA14, mph(A), arr-3, lnu(F)	4	AMP/CFZ/CTX/GEN/STR/TET/CHL/FFC/NAL/CIP/FOS/SXT	S83L D87N	S80I	pYUAHC39-MCR (IncI2, 63,924 bp)	IncA/C, IncFIB, IncHI2, IncI1, IncI2, IncY, Col(MG828)
AH20CE15	chicken, 2020	1589	bla_CTX−M−65, bla_TEM−1B, aadA1, aadA2, ΔaadA22, aac(3)-IVa, aac(3)-IId, aph(4)-Ia, aph(3’)-Ia, strAB, tet(A), tet(M), floR, cmlA1, oqxAB, mcr-1, sul1, sul2, dfrA12, mph(A), lnu(F)	4	AMP/CFZ/CTX/GEN/STR/TET/CHL/FFC/NAL/CIP/SXT	S83L D87N	S80I	contig 17 (IncHI2, 106,757 bp)	IncHI2, IncN, IncFII, IncFIB
AH20PE105	pig, 2020	14,521	mcr-1	4	None	None	None	pYUAHP105-MCR (IncI2, 60,733 bp)	IncI2, IncFII, IncFIB
AH20CE37	chicken, 2020	156	bla_CTX−M−55, bla_OXA−10, bla_TEM−1B, aadA1, ΔaadA22, aph(3’)-Ia, aph(3’)-IIa, aph(4)-Ia, aac(3)-IVa, strAB, tet(A), floR, cmlA1, qnrS1, fosA3, mcr-1, sul1, sul2, dfrA14, mph(A), arr-3, lnu(F)	4	AMP/CFZ/CTX/GEN/STR/TET/CHL/FFC/NAL/CIP/FOS/SXT	S83L D87N	S80I	pYUAHC37-MCR (IncI2, 64,657 bp)	IncA/C, IncFIB, IncHI2, IncI1, IncI2, IncY, Col(MG828)

^a Different locations are indicated as follows: XJ, Xinjiang Province; YZ, Yangzhou, Jiangsu Province; SD, Shandong Province; LN. Liaoning Province; AH, Anhui Province;
^b AMP, ampicillin; CFZ, cefazolin; CTX, cefotaxime; GEN, gentamicin; AMI, amikacin; TET, tetracycline; CHL, chloramphenicol; FFC, florfenicol; NAL, nalidixic acid; CIP, ciprofloxacin; FOS, fosfomycin; SXT, sulfamethoxazole/trimethoprim; STR, streptomycin

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