Table 3 Histopathological scores for wound healing parameters in control, Curcumin and CURC-NLCs groups during the first and third week

During 1st week

Control

Curcumin

CURC-NLCs

-

+

++

+++

-

+

++

+++

-

+

++

+++

Scab formation

0

0

1

4

0

0

3

2

0

1

3

1

Edema

0

0

2

3

0

1

3

1

0

2

2

1

Hemorrhage

0

0

2

3

0

1

3

1

0

2

2

1

Macrophage

0

1

1

3

0

1

3

1

0

0

3

2

Eosinophil

0

1

2

2

0

2

2

1

0

1

3

2

Angiogenesis

0

1

2

2

0

1

1

3

0

0

2

3

Fibroblasts activity

3

2

0

0

3

1

1

0

2

2

1

0

During 3rd week

Control

Curcumin

CURC-NLCs

-

+

++

+++

-

+

++

+++

-

+

++

+++

Fibroblasts activity

0

1

2

2

0

1

2

2

0

1

1

3

Re-epithelization

0

1

2

2

0

1

1

3

0

0

1

4

Rete ridges

3

2

0

0

0

1

1

3

0

0

2

3

Maturation of granulation tissue

0

1

2

2

0

1

2

2

0

1

1

3

Scar tissue formation

0

3

2

0

5

0

0

0

5

0

0

0