Impact of a combination of pimobendan, furosemide, and enalapril on heart rate variability in naturally occurring, symptomatic, myxomatous mitral valve degeneration dogs

Table 2 The correlation between variables of heart rate variability and indices of echocardiography, vertebral heart score, systolic blood pressure, and blood chemistry profiles in dogs with naturally occurring myxomatous mitral valve degeneration (MMVD) stage C

Correlation	LF	HF	TP	LF/HF	NNA	SDNN	pNN50%	rMSSD
LA/Ao	r= -0.097	r = 0.083	r = 0.081	r= -0.125	r = 0.282	r = 0.322	r = 0.319	r = 0.317
	P = 0.431	P = 0.500	P = 0.508	P = 0.312	P = 0.020	P = 0.007	P = 0.008	P = 0.008
LVIDDN	r = 0.068	r = 0.355	r = 0.311	r= -0.220	r = 0.255	r = 0.425	r = 0.464	r = 0.418
	P = 0.578	P = 0.003	P = 0.010	P = 0.071	P = 0.036	P < 0.001	P < 0.001	P = 0.001
SF	r = 0.002	r = 0.115	r = 0.072	r= -0.038	r= -0.027	r = 0.019	r = 0.088	r = 0.109
(mmHg)	P = 0.984	P = 0.351	P = 0.559	P = 0.754	P = 0.823	P = 0.872	P = 0.471	P = 0.376
VHS	r= -0.128	r= -0.086	r= -0.108	r = 0.030	r= -0.058	r= -0.217	r= -0.223	r= -0.132
	P = 0.469	P = 0.626	P = 0.542	P = 0.865	P = 0.741	P = 0.217	P = 0.204	P = 0.456
SBP	r= -0.166	r= -0.250	r= -0.242	r = 0.102	r= -0.238	r= -0.354	r= -0.290	r= -0.257
(mmHg)	P = 0.177	P = 0.040	P = 0.047	P = 0.409	P = 0.051	P = 0.003	P = 0.017	P = 0.034
BUN	r= -0.121	r= -0.233	r= -0.187	r= -0.055	r = 0.190	r = 0.041	r = 0.070	r = 0.054
(u/L)	P = 0.328	P = 0.056	P = 0.126	P = 0.652	P = 0.120	P = 0.739	P = 0.365	P = 0.661
Creatinine	r= -0.083	r= -0.190	r= -0.160	r = 0.067	r = 0.166	r = 0.019	r= -0.011	r= -0.047
(u/L)	P = 0.498	P = 0.120	P = 0.192	P = 0.584	P = 0.175	P = 0.874	P = 0.930	P = 0.704
ALT	r= -0.182	r= -0.220	r= -0.220	r = 0.039	r= -0.204	r= -0.303	r= -0.276	r= -0.238
(mg/dL)	P = 0.137	P = 0.072	P = 0.070	P = 0.748	P = 0.096	P = 0.012	P = 0.022	P = 0.050
ALKP	r= -0.138	r= -0.220	r= -0.230	r = 0.054	r= -0.119	r= -0.323	r= -0.333	r= -0.332
(mg/dL)	P = 0.263	P = 0.071	P = 0.060	P = 0.661	P = 0.334	P = 0.007	P = 0.005	P = 0.006

LF, low frequency; HF, high frequency; TP, total power; LF/HF, the ratio of LF to HF; NNA, an average of normal sinus NN durations in the entire recording; SDNN, the standard deviation of all normal sinus NN durations in the entire recording; pNN50, the percentage of the number of normal-to-normal sinus NN durations with differences > 50 ms calculated over the entire recording; rMSSD, the square root of the average of squared differences between adjacent normal sinus NN durations over the entire recording; LA/Ao, a left atrial-to-aortic root ratio; LVIDDN, a left ventricular internal diastole diameter normalized to body weight; SF, shortening fraction; VHS, vertebral heart score; SBP, systolic blood pressure; BUN, blood urea nitrogen; ALT, alanine transaminase; ALKP, alkaline phosphatase

ISSN: 1746-6148