Table 1 Time and frequency domain analysis parameters of heart rate variability in dogs with naturally occurring myxomatous mitral valve degeneration (MMVD) stage C before (baseline) and after treatment with a combination of pimobendan, furosemide, and enalapril assessed at baseline, 1 month (M1), 3 months (M3), and 6 months (M6)

469 ± 99

530 ± 133*

542 ± 130*

542 ± 137*

93 ± 42

137 ± 70*

144 ± 68*

143 ± 68*

74 ± 59

138 ± 110*

152 ± 112*

143 ± 110*

20 ± 20

38 ± 28*

40 ± 28*

39 ± 27*

1421 ± 831

2352 ± 2219

2854 ± 2891*

2887 ± 2530*

2597 ± 4980

9986 ± 15,038*

10,703 ± 14,167*

9661 ± 13,701*

7969 ± 7958

19,569 ± 22,171*

20,455 ± 23,302*

20,802 ± 21,413*

2.11 ± 2.20

1.12 ± 1.12*

0.90 ± 0.88

1.01 ± 0.91*