Table 3 Stability of UK-5099 in mouse plasma samples under various conditions (n = 6)
From: Determination and pharmacokinetics study of UK-5099 in mouse plasma by LC–MS/MS
Storage conditions | Concentration (ng/mL) | Accuracy ± SD (%) | RSD (%) |
|---|---|---|---|
Ambient temperature for 24 h | 15 | 115.47 ± 7.11 | 6.16 |
400 | 107.42 ± 4.65 | 4.65 | |
4000 | 106.67 ± 3.53 | 3.31 | |
At -20 °C for 60 days | 15 | 107.73 ± 9.12 | 8.47 |
400 | 108.75 ± 5.00 | 4.60 | |
4000 | 106.22 ± 6.01 | 5.66 | |
At 4 °C in the autosampler for 24 h | 15 | 95.11 ± 10.42 | 10.96 |
400 | 107.42 ± 4.65 | 4.33 | |
4000 | 104.08 ± 5.30 | 5.09 | |
Three Freeze–thaw cycles | 15 | 99.11 ± 6.71 | 6.77 |
400 | 108.75 ± 5.00 | 4.60 | |
4000 | 100.33 ± 2.27 | 2.26 |