From: Functional phenotyping of the CYP2D6 probe drug codeine in the horse
Parameter | Predicted phenotype | ||
---|---|---|---|
Poor (n = 11) | Extensive (n = 72) | Ultra-rapid (n = 17) | |
Codeine AUC0-∞ (h·ng/mL) | 257.72 ± 122.93b,c | 76.49 ± 46.35a,c | 20.84 ± 6.33a,b |
C6G AUC0-∞ (h·ng/mL) | 500.15 ± 249.83 | 630.12 ± 331.76 | 523.38 ± 209.18 |
Morphine AUC0-∞ (h·ng/mL) | 27.46 ± 9.14 | 30.82 ± 10.26 | 34.66 ± 6.31 |
M3G AUC0-∞ (h·ng/mL) | 2700.64 ± 892.03c | 3277.89 ± 935.74 | 3904.93 ± 987.01a |
M6G AUC0-∞ (h·ng/mL) | 98.25 ± 32.76b,c | 170.32 ± 71.02a | 180.92 ± 65.70a |
MR O-demethylation | 0.089 ± 0.027b,c | 0.022 ± 0.011a,c | 0.0095 ± 0.001a,b |
MR glucuronidation | 0.711 ± 0.596b,c | 0.153 ± 0.137a | 0.045 ± 0.020a |
Codeine t1/2d (h) | 1.32 ± 0.56 | 2.50 ± 1.37 | 2.24 ± 0.88 |