Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand

Phochantachinda, Sataporn; Chantong, Boonrat; Reamtong, Onrapak; Chatchaisak, Duangthip

doi:10.1186/s12917-021-02744-w

BMC Veterinary Research

Table 2 Downregulated and upregulated proteins in comparisons of the CCDS group with both the adult and the ageing

From: Change in the plasma proteome associated with canine cognitive dysfunction syndrome (CCDS) in Thailand

Accession number^a	Protein name	Protein mass	pI	Protein score	Biological process	P-value
Downregulated proteins
gi\|345792424	alpha-2-macroglobulin	165114	6.27	101	negative regulation of complement activation	p = 0.0144
gi\|545487024	alpha-1B-glycoprotein	61261	5.81	47	platelet degranulation	p = 0.0001
gi\|345778397	complement factor B	86266	7.18	75	regulation of complement activation	p = 0.1544
gi\|545544683	immunoglobulin lambda-like polypeptide 5-like	24739	6.41	1116	innate immune response	p = 0.0049
Upregulated proteins
gi\|73955106	apolipoprotein A-I	30163	5.28	2244	lipoprotein metabolic process	p = 0.0136
gi\|704000372	apolipoprotein A-IV	42510	5.75	318	removal of superoxide radicals	p < 0.0001
gi\|345799905	predict apolipoprotein A-IV	43795	5.34	615	removal of superoxide radicals	p < 0.0001
gi\|545488191	apolipoprotein E isoform X5	47029	8.45	88	regulation of amyloid beta clearance	N/A
gi\|73978329	fibrinogen alpha chain	96583	5.76	275	blood coagulation	p = 0.002
gi\|73977992	fibrinogen gamma chain isoformX1	49286	5.74	1092	blood coagulation	p < 0.0001
gi\|120141	fibrinogen gamma chain, partial	2688	4.55	93	blood coagulation	p = 0.201
gi\|57109938	kininogen-1	48317	5.58	104	blood coagulation	p < 0.0001
gi\|545485785	plasminogen isoformX1	90952	6.75	121	blood coagulation	p = 0.1496
gi\|130314	plasminogen	36654	8.48	152	blood coagulation	p < 0.0001
gi\|123511	haptoglobin	36434	5.72	2272	acute phase response	p = 0.0001
gi\|545560457	inter-alpha-trypsin inhibitor heavy chain H4 isoformX1	113355	7.1	292	acute phase response	p < 0.0001
gi\|359321961	prothrombin	70259	5.71	42	acute phase response and blood coagulation	N/A
gi\|345803075	C4b-binding protein alpha chain isoform X1	68505	7.77	171	complement activation classical pathway	p < 0.0001
gi\|50979240	clusterin precursor	51757	5.65	107	complement activation and regulation of Aβ formation	p < 0.0001
gi\|598107	IgA heavy chain constant region	37255	6.06	114	complement activation classical pathway	p < 0.0001
gi\|19715661	Ig J chain	12733	4.94	38	innate immune response	p = 0.0789
gi\|73995687	Ig lambda-like polypeptide 5-like	14832	8.84	1528	complement activation classical pathway	p < 0.0001
gi\|345777714	alpha-1-acid glycoprotein 1 isoform X1	23291	5.38	45	regulation of immune response	p = 0.0245
gi\|545531456	plasma protease C1 inhibitor	48,128	5.51	88	complement activation classical pathway	p < 0.0001
gi\|50978658	alpha-fetoprotein precursor	68738	5.77	52	cellular protein metabolic process	p = 0.027
gi\|256574824	glutathione peroxidase 3 precursor	25363	8.79	59	response to oxidative stress	p < 0.0001
gi\|44888810	hemoglobin alpha chain	15208	7.98	267	cellular oxidant detoxification	p < 0.0001
gi\|73988725	hemopexin	51305	6.88	149	heme metabolic process	p < 0.0001
gi\|119637837	pigment epithelium-derived factor	44236	8.69	40	aging	p < 0.0001
gi\|57089193	transthyretin isoform 2	15858	6.42	619	retinol, thyroid hormone transport	p = 0.001

^a Accession number from NCBInr database for Canis spp.
N/A = cannot measure by ANOVA because the samples all have a standard error of zero.

Back to article page

ISSN: 1746-6148

Contact us

General enquiries: journalsubmissions@springernature.com