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Table 1 Effects of Ivermectin cream on Macroscopic Wound Healing Indices

From: Mechanisms of ivermectin-induced wound healing

WOUND HEALING INDICES

CONTROL

SILVER SULFADIAZINE

IVERMECTIN CREAM (% W/W)

1

0.3

0.1

0.03

Exudation Index

0.30 ± 0.18

0.25 ± 0.16**

0.25 ± 0.16**

0.13 ± 0.12***

0.13 ± 0.12***

0.00 ± 0.00****

Edge Edema Index

2.63 ± 0.96

2.38 ± 0.90*

2.13 ± 0.81**

1.88 ± 0.87**

1.63 ± 0.80***

1.25 ± 0.77***

Hyperaemia Index

2.00 ± 0.94

2.00 ± 0.94*

1.75 ± 0.96*

1.88 ± 0.93**

1.63 ± 0.96****

1.63 ± 0.96****

Granulation Tissue Index

4.00 ± 0.60

2.38 ± 0.92*

2.25 ± 0.86*

1.88 ± 0.87**

1.63 ± 0.80***

1.25 ± 0.77****

  1. Sprague Dawley rats were anaesthetised as described in the methods. Excision wounds were created and evaluated systematically on days 0, 2, 5, 7, 9, 13, 15 and 21 for macroscopic wound healing indices (0 = Absent, 1–2 = Mild, 3–4 = Moderate, 5–6 = Severe). Data is present as mean ± SEM of wound exudation indices. Statistical analysis is by One-way ANOVA. * means p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 when compared to control using Bonferroni's post hoc test
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BMC Veterinary Research

ISSN: 1746-6148

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