Fig. 3
Vacuolation profiles of TgBovXV mice intracranially inoculated with various TSE strains. a The degree of vacuolation was plotted (mean ± SEM) against predefined neuroanatomic locations to generate the lesion profile. The pattern of the profiles is most similar between o-bTMEVV (solid cyan line), L-BSE (solid black line), and bTME (dotted blue line) with some minor variations in the degree of vacuolation. C-BSE (red dashed line) and o-bTMEAV (solid pink line) have distinct lesion patterns compared to bTME, o-bTMEVV, and L-BSE. Vacuolation profiles are displayed with the absolute values of the difference between the plotted means (green bar) of (b) o-bTMEVV vs. L-BSE, (c) o-bTMEVV vs. bTME, (d) L-BSE vs. bTME, and (e) o-bTMEAV vs. C-BSE. A horizontal dashed-green line intersects the y-axis at 1 indicating a subjective threshold to gauge the relative intensity of vacuolation. Medulla (G1), cerebellum (G2), midbrain (G3), hypothalamus (G4), thalamus (G5), hippocampus (G6), para terminal body (G7), and cerebral cortex (G8 and G9). White matter in the cerebellar peduncle (W1), lateral tegmentum (W2), and the internal capsule (W3)