Parameters | Dose Groups | ||
---|---|---|---|
0.25 mg/kg (n = 7) | 0.5 mg/kg (n = 8) | 1.0 mg/kg (n = 8) | |
C(0) ng/mL | 540.9 ± 142.9c | 691.9 ± 123.1c | 987.7 ± 224.6ab |
Lambdaz(1/h) | 0.358 ± 0.157b | 0.245 ± 0.139a | 0.207 ± 0.062 |
HL Lambdaz (h) | 1.93 ± 1.39c | 2.82 ± 2.10 | 3.35 ± 0.940a |
Vdss (L/kg) | 0.829 ± 0.138bc | 1.08 ± 0.194ac | 1.58 ± 0.280ab |
CL (mL/min/kg) | 18.0 ± 1.40c | 19.3 ± 3.03c | 22.8 ± 3.60ab |
AUC0 − inf (h*ng/mL) | 232.7 ± 19.4bc | 442.8 ± 73.1ac | 748.3 ± 125.5ab |