Table 4 Pharmacokinetic (PK) variables following intravenous (IV), intramuscular (IM) or subcutaneous (SC) administration of buprenorphine (Simbadol; 0.02 mg/kg) in dogs undergoing ovariohysterectomy. Data are reported as mean (95% confidence interval)

AUC _0-t

ng/mL*h

14.49 (12.86–16.11)

9.32 (6.53–12.11)

5.79 (4.26–7.32)

AUC _0-∞

ng/mL*h

15.77 (13.87–17.67)

12.41 (10.39–14.43)

16.45 (8.00–24.90)

C₀ or Cmax

ng/mL

35.92 (14.42–57.43)

6.24 (2.78–9.70)

1.37 (0.89–1.85)

F

%

–

62.6

40

Tmax

h

–

0.14 (0.01–0.26)

0.33 (0.20–0.47)

λ z

1/h

0.19 (0.17–0.21)

0.14 (0.10–0.18)

0.04 (0.02–0.06)

t_1/2

h

3.69 (3.25–4.14)

5.66 (2.82–8.50)

21.95 (12.03–31.87)

MRT_0-∞

h

3.59 (3.06–4.12)

7.37 (3.00–11.73)

30.02 (15.77–44.27)

Cl or Cl/F

L/h/kg

1.29 (1.14–1.45)

1.65 (1.40–1.91)

1.40 (0.91–1.88)

V_z or V_z/F

L/kg

6.82 (6.06–7.58)

14.16 (4.50–23.81)

40.13 (26.27–53.98)

V_ss

L/kg

4.59 (3.98–5.19)

NC

NC