Table 2 Changes in the serum biochemicals during the induction of PH (63 days) in the control (n = 10) and PH-induced (n = 10) groups of intact dogs

0

21

42

63

Glucose (mg/dl)

Control

62.7 ± 4.32^a

87.3 ± 2.35^b

87.7 ± 4.84*^b

93.55 ± 3.85^b

PH Induction

65.55 ± 3.31^a

86.65 ± 2.69^b

67.9 ± 3.54*^a

89.85 ± 1.6^b

Urea (mg/dl)

Control

47.85 ± 11.32

30.05 ± 2.93

42.6 ± 2.76

40.2 ± 2.98

PH Induction

43.95 ± 5.52

33.9 ± 2.68

43.89 ± 2.26

41.1 ± 3.08

Creatinine (mg/dl)

Control

1.022 ± 0.08^a

0.9591 ± 0.04^b

0.79 ± 0.06^b

0.816 ± 0.05^b

PH Induction

1.074 ± 0.04^a

0.997 ± 0.03

0.914 ± 0.05^b

0.846 ± 0.06

TriGlycerides (mg/dl)

Control

45.7 ± 4.3^ac

39.25 ± 2.88^a

57.1 ± 5.34^c

58.6 ± 4.42^c

PH Induction

37.4 ± 2.07^a

41.75 ± 2.06

51.45 ± 3.01^b

50.85 ± 4.07^b

Cholesterol (mg/dl)

Control

187.9 ± 11.49

162.8 ± 15.18

168.6 ± 10.78

196.1 ± 11.92

PH Induction

185.1 ± 13.75

173.4 ± 10.87

146.2 ± 10.2

169.5 ± 12.91

AST (U/L)

Control

29.63 ± 2.74^a

16.56 ± 0.59^b

20.26 ± 1.12^ab

24.71 ± 2.86^ab

PH Induction

33.2 ± 1.97^a

17.5 ± 0.98^b

21.26 ± 2.83^b

19.26 ± 1.61^b

ALT (U/L)

Control

32.82 ± 4.6^a

26.23 ± 1.54^a

40.35 ± 4.5

50.65 ± 7.34^b

PH Induction

26.51 ± 2.71

24.98 ± 3.6

41.59 ± 6.05

40.7 ± 4.22

ALP (U/L)

Control

122.75 ± 20.02

115.5 ± 24.86

110.3 ± 21.02

120.95 ± 19.59

PH Induction

106.2 ± 10.01

134.68 ± 16.83

131 ± 17.97

116.45 ± 15.78

Ca (mg/dl)

Control

11.06 ± 0.22^a

9.83 ± 0.24^b

9.97 ± 0.24^b

9.89 ± 0.21^b

PH Induction

10.38 ± 0.21^a

9.6 ± 0.14

9.36 ± 0.13 ^b

9.77 ± 0.2

P (mg/dl)

Control

4.93 ± 0.2^a

4.64 ± 0.24

3.96 ± 0.16^b

4.65 ± 0.34

PH Induction

5.21 ± 0.24

4.43 ± 0.16

4.46 ± 0.09

4.69 ± 0.21

Total protein (g/dl)

Control

5.13 ± 0.19

4.84 ± 0.2

4.5 ± 0.09

5.09 ± 0.26

PH Induction

5.21 ± 0.24

4.73 ± 0.12

4.58 ± 0.11

4.72 ± 0.17

Albumin (g/dl)

Control

3.28 ± 0.11

2.84 ± 0.09

2.94 ± 0.12

2.86 ± 0.1

PH Induction

3.41 ± 0.15^a

2.77 ± 0.08^b

2.72 ± 0.07^b

2.76 ± 0.1^b

Na (mEq/L)

Control

126.8 ± 1.91

127.8 ± 1.9

128.1 ± 1.96

136.5 ± 3.55

PH Induction

132.5 ± 4.07

124.1 ± 1.62

124.9 ± 1.23

135.2 ± 5.4

K (mg/dl)

Control

3.81 ± 0.16

3.9 ± 0.16

3.33 ± 0.1

3.37 ± 0.12

PH Induction

4.12 ± 0.22^a

3.57 ± 0.08

3.26 ± 0.13^b

3.4 ± 0.1^b