Time (hours post induction) | Control | Firocoxib | Grapiprant |
---|---|---|---|
Experiment 1 - treatments administered 2 h prior to induction of arthritis | |||
0 (pre-arthritis induction) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
1.5 | 2 (0–5) | 0 (0–2) | 2 (0–5) |
3 | 5 (5–5) | 0 (0–3) | 4 (1–5) |
5 | 5 (5–5) | 0 (0–0) | 5 (5–5) |
7 | 5 (5–5) | 0 (0–0) | 5 (4–5) |
10 | 5 (5–5) | 0 (0–0) | 4 (1–5) |
Experiment 2 - treatments administered 14 h prior to induction of arthritis | |||
0 (pre-arthritis induction) | 0 (0–0) | 0 (0–0) | 0 (0–0) |
1.5 | 5 (4–5) | 2 (0–5) | 2 (0–5) |
3 | 5 (5–5) | 3 (0–5) | 5 (4–5) |
5 | 5 (5–5) | 4 (0–5) | 5 (5–5) |
7 | 5 (5–5) | 1 (0–5) | 5 (5–5) |
10 | 4 (0–5) | 0 (0–1) | 5 (5–5) |