Table 2 Relationship between overall survival (OS) and clinicopathological variables in 33 cases of feline non-ocular melanocytic tumors with available follow-up information
From: Evaluation of Ki-67 expression in feline non-ocular melanocytic tumours
Variables | Number of cases | Median OS (95% CI)c | P |
|---|---|---|---|
Tumor location | 0.036* | ||
Skin | 21 | 197 (133–261) | |
Mucosae | 12 | 72 (48–96) | |
Largest diametera | 0.006* | ||
≤ 1.3 cm | 14 | 689 (79–1299) | |
> 1.3 cm | 19 | 75 (11–139) | |
Morphological diagnosis | 0.109 | ||
Melanocytoma | 3 | Not reached | |
Melanoma | 30 | 156 (91–221) | |
Prevalent histotype | 0.014* | ||
Spindle, balloon and signet ring cell | 10 | 48 (0–115) | |
Epithelioid | 9 | 689 (0–1444) | |
Mixed | 14 | 156 (125–187) | |
Junctional activity | 0.412 | ||
Present | 10 | 136 (101–171) | |
Absent | 23 | 197 (120–273) | |
Pigmentation | 0.015* | ||
≥ 50% | 8 | Not reached | |
< 50% or absent | 25 | 119 (29–208) | |
Vascular invasion | 0.809 | ||
Present | 6 | 176 (0–405) | |
Absent | 27 | 156 (77–235) | |
Lymphocytic infiltrate | 0.838 | ||
present | 12 | 176 (39–313) | |
absent | 21 | 156 (92–219) | |
Necrosis | 0.681 | ||
present | 7 | 197 (48–346) | |
absent | 26 | 156 (116–196) | |
Mitotic countb | 0.013* | ||
≤ 5 | 9 | 689 (0–1451) | |
> 5 | 24 | 119 (32–206) | |
Ki-67 indexb | 0.036* | ||
≤ 20% | 10 | 689 (0–1460) | |
> 20% | 23 | 119 (34–204) | |
Treatment | < 0.001* | ||
Yes | 21 | 689 (12–1366) | |
No | 12 | 59 (20–98) | |