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Table 6 Mean scores of all dogs for cytology scores, microbiological responses, pain and pruritus scores

From: A randomized, controlled, single-blinded, multicenter evaluation of the efficacy and safety of a once weekly two dose otic gel containing florfenicol, terbinafine and betamethasone administered for the treatment of canine otitis externa

 

D0

D7

D28

D56

Gel

Suspension

p-value

Gel

Suspension

p-value

Gel

Suspension

p-value

Gel

Suspension

p-value

Cytology (Mean +/− SD)

 Bacteria

1.7 +/− 0.8

1.7 +/− 0.8

0.7479

n/a

n/a

n/a

1.1 +/−  0.9

0.9 +/−  0.7

0.2160

1.1 +/− 1.0

0.9 +/− 1.0

0.2233

 Yeasts

2.1 +/− 0.8

2.2 +/− 0.8

0.3957

n/a

n/a

n/a

1.3 +/− 0.8

1.5 +/− 0.8

0.1077

1.5 +/− 0.9

1.5 +/−  0.9

0.4040

 Neutrophils

1.2 +/− 0.4

1.3 +/− 0.7

0.6431

n/a

n/a

n/a

0.5 +/− 0.7

0.4 +/− 0.8

0.3488

0.5 +/− 0.7

0.4 +/−  0.9

0.2335

Bacteriological Response (%)

n/a

n/a

n/a

   

60

60

1.0000

49

55

0.4501

Fungal Response (%)

n/a

n/a

n/a

   

76

69

0.3318

65

55

0.1824

Investigator Pain Score (est. +/− SE)

1.77 +/− 0.07

1.69 +/− 0.07

0.4406

0.45 +/− 0.05

0.55 +/−  0.05

0.2371

0.38 /−  0.06

0.46 +/−  0.06

0.2967

0.42 +/−  0.06

0.54 +/−  0.07

0.1860

Owner Pain VAS (est. +/− SE)

31.4 +/− 2.8

31.1 +/− 2.9

0.9499

8.3 +/−  0.8

6.8 +/−  0.7

0.1437

3.9 +/−  0.5

3.3 +/−  0.4

0.3984

3.8 +/−  0.5

4.1 +/−  0.6

0.7676

Owner Pruritus VAS (est. +/− SE)

50.2 +/− 3.2

52.5 +/− 3.4

0.6334

10.8 +/− 1.1

7.8 +/−  0.8

0.0232

5.0 +/−  0.6

4.3 +/−  0.6

0.423

5.1 +/−  0.8

5.2 +/−  0.8

0.9208

  1. Est. Estimated, S.E. Standard error, VAS Visual analog scale, SD Standard deviation; Entries in italic font are statistically significant