Table 4 Summary data of histology
Tissue | Group 1 (sham) | Group 2 (2 mg/kg) | Group 3 (6 mg/kg) | Group 4 (10 mg/kg) |
|---|---|---|---|---|
Observation, severity (localization) | ||||
Adrenal glands | ||||
Normal | 8 | 8 | 8 | 8 |
Aorta | ||||
Normal | 8 | 8 | 8 | 8 |
Bone marrow | ||||
Normal (femur) | 8 | 8 | 8 | 8 |
Normal (rib) | 8 | 8 | 8 | 8 |
Normal (sternum) | 8 | 8 | 8 | 8 |
Bone | ||||
Normal (femur) | 7 | 7 | 8 | 8 |
Cartilage degeneration, minimal (femur) | 1 | 1 | 0 | 0 |
Normal (rib) | 8 | 8 | 8 | 8 |
Normal (sternum) | 8 | 8 | 8 | 8 |
Brain | ||||
Normal | 7 | 8 | 8 | 8 |
Gliosis, minimal | 1 | 0 | 0 | 0 |
Eyes, optic nerves | ||||
Normal | 8 | 8 | 8 | 8 |
Gallbladder | ||||
Normal | 8 | 8 | 8 | 8 |
Gastronintestinal tract | ||||
Normal (esophagus) | 8 | 8 | 8 | 8 |
Normal (stomach) | 8 | 8 | 8 | 7 |
Focal mineralization, minimal (stomach, cardia) | 0 | 0 | 0 | 1 |
Normal (duodenum) | 8 | 8 | 8 | 8 |
Normal (ileum) | 8 | 8 | 7 | 8 |
Mucosal atrophy, minimal (ileum) | 0 | 0 | 1 | 0 |
Normal (jejunum) | 8 | 8 | 8 | 8 |
Normal (cecum) | 8 | 8 | 8 | 8 |
Normal (colon) | 7 | 8 | 8 | 8 |
Cyst, mild (colon) | 1 | 0 | 0 | 0 |
Normal (rectum) | 8 | 8 | 8 | 8 |
Gonads | ||||
Normal (ovaries) | 4 | 4 | 4 | 4 |
Normal (testis) | 2 | 4 | 3 | 3 |
Seminiferous tubules hypoplasia, minimal (testis) | 2 | 0 | 1 | 1 |
Hypospermatogenesis, moderate (testis) | 1 | 0 | 0 | 0 |
Heart | ||||
Normal | 7 | 8 | 8 | 8 |
Hematocyst, minimal (valvular) | 1 | 0 | 0 | 0 |
Kidneys | ||||
Normal | 0 | 1 | 0 | 0 |
Lymphocytic infiltration, minimal | 0 | 1 | 1 | 0 |
Tubular mineralization, minimal | 8 | 7 | 8 | 8 |
Tubular regeneration, minimal | 1 | 0 | 0 | 0 |
Liver | ||||
Normal | 8 | 7 | 7 | 4 |
Mononuclear infiltrate, minimal | 0 | 1 | 1 | 4 |
Lung | ||||
Normal | 0 | 1 | 2 | 1 |
Hemorrhage, minimal | 0 | 0 | 0 | 1 |
Alveolar histiocytosis, minimal or mild | 6 | 6 | 4 | 5 |
Lymphocytic infiltration, minimal | 6 | 3 | 3 | 3 |
Subacture inflammation, minimal | 0 | 0 | 2 | 0 |
Lymph nodes | ||||
Normal (mandibular) | 8 | 8 | 8 | 8 |
Normal (mesenteric) | 8 | 8 | 8 | 8 |
Normal (tracheobronchial) | 8 | 8 | 8 | 8 |
Pancreas | ||||
Normal | 7 | 8 | 8 | 8 |
Lymphocytic infiltration, minimal | 1 | 8 | 8 | 8 |
Pituitary | ||||
Normal | 6 | 8 | 6 | 7 |
Cyst, minimal or mild | 2 | 0 | 2 | 1 |
Prostate | ||||
Normal | 4 | 4 | 1 | 4 |
Lymphocitic infiltration, minimal or mild | 0 | 0 | 3 | 0 |
Salivary gland | ||||
Normal | 6 | 7 | 6 | 8 |
Lymphocytic infiltration, minimal | 2 | 1 | 2 | 0 |
Skeletal muscle | ||||
Normal | 8 | 8 | 8 | 8 |
Skin | ||||
Normal | 8 | 8 | 8 | 8 |
Spinal cord (cervical, thoracic and lumbar) | ||||
Normal | 8 | 8 | 8 | 8 |
Spleen | ||||
Normal | 8 | 8 | 8 | 8 |
Thymus | ||||
Normal | 0 | 0 | 1 | 1 |
Cyst, minimal or mild | 2 | 4 | 0 | 3 |
Lymphoid depletion, minimal to moderate | 8 | 8 | 7 | 6 |
Thyroid | ||||
Normal | 8 | 8 | 8 | 8 |
Trachea | ||||
Normal | 8 | 8 | 8 | 8 |
Urinary bladder | ||||
Normal | 8 | 8 | 8 | 8 |
Uterus with cervix | ||||
Normal | 3 | 3 | 4 | 4 |
Cyst, mild | 1 | 0 | 0 | 0 |
Pseudocyesis, mild | 0 | 1 | 0 | 0 |
Vagina | ||||
Normal | 8 | 8 | 8 | 8 |