Table 3 Allelic and genotypic distribution of non-synonymous mutation found in LGI1–4 in familial spontaneous epileptic cats (FSECs) and controls
| Â | Nucleotide | Amino Acid | SIFT prediction | PP2 prediction | PROVEAN prediction | Group (n) | Genotype frequencies | Allele frequencies | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
LGI3 | Â | Â | Â | Â | Â | Â | C/C | C/G | G/G | f(C) | f(G) |
|  | c.97C > G | p.P33A | Deleteriouss | Benign | Neutral | FSECs(8) | 8 | 0 | 0 | 1 | 0 |
| Â | Â | Â | Â | Â | Â | Controls(8) | 7 | 1 | 0 | 0.9375 | 0.0625 |
LGI4 | Â | Â | Â | Â | Â | Â | G/G | G/A | A/A | f(G) | f(A) |
|  | c.49G > A | p.A17T | Tolerated | Unknown | Neutral | FSECs(8) | 8 | 0 | 0 | 1 | 0 |
| Â | Â | Â | Â | Â | Â | Controls(8) | 7 | 1 | 0 | 0.9375 | 0.0625 |
| Â | Â | Â | Â | Â | Â | Â | G/G | G/A | A/A | f(G) | f(A) |
|  | c.145G > A | p.E49K | Tolerated | Benign | Neutral | FSECs(8) | 5 | 3 | 0 | 0.8125 | 0.1875 |
| Â | Â | Â | Â | Â | Â | Controls(8) | 8 | 0 | 0 | 1 | 0 |