Table 2 Sensitivities and specificities at the optimal cut-off concentrations (expressed as the fold elevation above the respective URL for the assay) and area under the ROC curve (AUROC) for serum gastrin concentrations to distinguish acid-suppressant (H2A and/or PPI)-treated or acid-suppressant-naïve dogs with CE from dogs diagnosed with gastrinoma (n = 14 historical positive controls)

all CE dogs vs. gastrinoma^a

97%

>1.8 × URL

>3.2 × URL

acid-suppressant-naïve CE dogs vs. gastrinoma^a

98%

>1.8 × URL

>3.2 × URL

acid-suppressant-treated CE dogs vs. gastrinoma^a

95%

>1.8 × URL

>10.3 × URL

H2A-treated CE dogs vs. gastrinoma^a

97%

>1.8 × URL

>3.2 × URL

PPI-treated CE dogs vs. gastrinoma^a

91%

>3.2 × URL

>10.3 × URL