Fig. 2
From: Evaluation of P16 expression in canine appendicular osteosarcoma
The organization and appearance of slides derived from canine OSA TMA stained with H&E stains or anti-P16 antibody (IHC). The TMA are arranged in 9 columns (1–9) by 6 rows (A-F) comprising a 9 × 6 grid. The majority of 2 mm diameter biopsy cores are present in hematoxylin & eosin-stained slides (TMA4) (a) and anti-P16 IHC (TMA3) (b). The outer row (columns 1 and 9, rows A and F) are generally comprised of negative control tissue (canine renal cortical or brain tissue). Triplicate canine OSA biopsy (test) samples are located within the boxed regions and are identified by case numbers (b). The location of positive control samples (GBM) are indicated (+) (b)