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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach

Fig. 5

Simulated data for the plasma tulathromycin concentrations (a, b), cumulative excreted amounts of marker residue CP-60,300 in milk (c, d), milk concentrations (e, f) of CP-60,300 in lactating goats after single or twice injections. The solid and dashed black lines represent the 95th and 50th percentiles of the simulated data, respectively. The solid and dotted red lines represent limit of detection (LOD) and limit of quantification (LOQ), respectively, in milk (LOD = 1.8 ng/mL, LOQ = 5 ng/ml) and plasma (LOD = 1.2 ng/mL, LOQ = 4 ng/ml). The empty purple circles represent the measured data from Grismer et al. [12] and the present pharmacokinetic study

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