An immunohistochemical study on the expression of sex steroid receptors, Ki-67 and cytokeratins 7 and 20 in feline endometrial adenocarcinomas

Table 3 Results for the immunoexpression of the ER-α and PR in the normal feline uterus (at the FS and LS) and in the neoplastic epithelium in FEA

		Intensity				Percentage of positive cells
		n (%)				n (%)
		0	1	2	3	0	1	2
		ER-α
FS	SE	0	0	7 (53.8)	6 (46.2)	0	0	13 (100.0)
	SGE	0	0	3 (23.1)	10 (76.9)	0	0	13 (100.0)
	DGE	0	0	1 (7.7)	12 (92.3)	0	0	13 (100.0)
	Stroma	0	0	4 (30.8)	9 (69.2)	0	7 (53.8)	6 (46.2)
	Myometrium	0	0	12 (92.3)	1 (7.7)	0	0	13 (100.0)
LS	SE	0	3 (30.0)	5 (50.0)	2 (20.0)	0	2 (20.0)	8 (80.0)
	SGE	0	0	6 (60.0)	4 (40.0)	0	0	10 (100.0)
	DGE	0	0	0	10 (100.0)	0	0	10 (100.0)
	Stroma	0	1 (10.0)	4 (40.0)	5 (50.0)	0	7 (70.0)	3 (30.0)
	Myometrium	0	1 (10.0)	7 (70.0)	2 (20.0)	0	0	10 (100.0)
FEA	Epithelium	12 (50.0)	5 (20.8)	6 (25.0)	1 (4.2)	12 (50.0)	11 (45.8)	1 (4.2)
	Stroma	11 (45.8)	2 (8.3)	8 (33.3)	3 (12.5)	11 (45.8)	13 (54.2)	0
	Myometrium	4 (16.7)	0	18 (75.0)	2 (8.3)	4 (16.7)	9 (37.5)	11 (45.8)
		PR
FS	SE	0	1 (7.7)	7 (53.8)	5 (38.5)	0	0	13 (100.0)
	SGE	0	1 (7.7)	7 (61.5)	5 (30.8)	0	0	13 (100.0)
	DGE	0	2 (15.4)	5 (38.5)	6 (46.2)	0	0	13 (100.0)
	Stroma	0	1 (7.7)	10 (76.9)	2 (15.4)	0	10 (76.9)	3 (23.1)
	Myometrium	0	5 (38.5)	8 (61.5)	0	0	0	13 (100.0)
LS	SE	0	0	5 (50.0)	5 (50.0)	0	1 (10.0)	9 (90.0)
	SGE	0	0	5 (50.0)	5 (50.0)	0	1 (10.0)	9 (90.0)
	DGE	0	1 (10.0)	3 (30.0)	6 (60.0)	0	1 (10.0)	9 (90.0)
	Stroma	4 (40.0)	1 (10.0)	2 (20.0)	3 (30.0)	4 (40.0)	6 (60.0)	0
	Myometrium	1 (10.0)	4 (40.0)	3 (30.0)	2 (20.0)	1 (10.0)	2 (20.0)	7 (70.0)
FEA	Epithelium	0	1 (4.2)	19 (79.2)	4 (16.7)	0	7 (29.2)	17 (70.8)
	Stroma	2 (8.3)	1 (4.2)	19 (79.2)	2 (8.3)	2 (8.3)	21 (87.5)	1 (4.2)
	Myometrium	0	4 (16.7)	18 (75.0)	2 (8.3)	0	6 (25.0)	18 (75.0)

SE = surface endometrium; SGE = superficial glandular epithelium; DGE = deep glandular epithelium; FS = follicular stage; LS = luteal stage.). Intensity of immunolabelling: 1 = weak, 2 = moderate and 3 = strong. Percentage of positive nuclei: 0 = negative (≤5 % positive nuclei); 1 = loss of expression (5-80 % positive nuclei) and 2 = positive (≥80 % positive nuclei)

ISSN: 1746-6148