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Table 1 Isoflurane – mean values with standard deviation

From: Influence of repeated anaesthesia on physiological parameters in male Wistar rats: a telemetric study about isoflurane, ketamine-xylazine and a combination of medetomidine, midazolam and fentanyl

Parameter

Run

Baseline

Induction

Non-surgical tolerance

Surgical tolerance

Wake-up

Recovery

 

(No. of animals)

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

SAP (mmHg)

1 (6)

121 ± 11.33

141 ± 13.09

133 ± 15.24

117 ± 7.76

123 ± 12.44

122 ± 11.41

2 (6)

120 ± 11.55

140 ± 10.78

128 ± 16.02

113 ± 9.33

121 ± 10.11

122 ± 10.94

3 (6)

121 ± 7.72

140 ± 11.81

130 ± 12.45

114 ± 8.71

123 ± 8.63

122 ± 8.45

4 (6)

120 ± 13.04

139 ± 12.48

130 ± 12.84

111 ± 9.11

120 ± 12.45

119 ± 9.77

5 (6)

115 ± 18.93

134 ± 16.08

124 ± 18.84

104 ± 16.35*

112 ± 20.32

116 ± 14.24

6 (5)

120 ± 8.00

139 ± 9.83

129 ± 14.88

106 ± 12.51*

120 ± 16.26

121 ± 8.87

DAP (mmHg)

1 (6)

90 ± 7.73

106 ± 11.97

97 ± 12.48

85 ± 6.96

87 ± 11.22

92 ± 7.94

2 (6)

89 ± 10.32

105 ± 10.06

92 ± 14.54

81 ± 7.68

86 ± 7.95

91 ± 8.58

3 (6)

89 ± 6.26

103 ± 10.88

93 ± 9.52

82 ± 7.54

87 ± 5.22

91 ± 7.24

4 (6)

88 ± 9.13

102 ± 10.85

93 ± 9.39

79 ± 6.44

85 ± 7.16

90 ± 8.45

5 (6)

85 ± 11.05

101 ± 9.30

90 ± 10.33

75 ± 7.76*

80 ± 9.46

89 ± 8.00

6 (5)

89 ± 7.55

103 ± 6.26

93 ± 10.85

75 ± 7.84*

84 ± 9.10

91 ± 7.64

MAP (mmHg)

1 (6)

100 ± 8.43

118 ± 11.99

109 ± 13.10

96 ± 6.72

99 ± 11.21

102 ± 8.72

2 (6)

99 ± 10.48

116 ± 9.96

104 ± 14.79

92 ± 7.99

97 ± 8.36

101 ± 9.12

3 (6)

100 ± 6.46

116 ± 10.94

105 ± 10.21

93 ± 7.41

99 ± 5.71

102 ± 7.31

4 (6)

99 ± 10.20

115 ± 11.11

105 ± 10.28

90 ± 6.93

97 ± 8.68

100 ± 8.79

5 (6)

95 ± 13.43

112 ± 11.17

102 ± 12.93

85 ± 10.42*

90 ± 13.00

98 ± 9.86

6 (5)

100 ± 7.28

115 ± 7.01

105 ± 11.92

85 ± 9.16*

96 ± 11.40

101 ± 7.69

PP (mmHg)

1 (6)

32 ± 7.21

35 ± 6.27

36 ± 6.57

32 ± 5.69

35 ± 6.65

30 ± 6.49

2 (6)

31 ± 5.01

35 ± 5.63

35 ± 5.84

32 ± 4.55

35 ± 5.33

30 ± 5.14

3 (6)

32 ± 4.40

37 ± 5.07*

37 ± 5.89

32 ± 6.14

36 ± 6.83

31 ± 4.86

4 (6)

31 ± 6.06

37 ± 5.58*

37 ± 5.99

32 ± 5.72

35 ± 6.88

30 ± 3.14

5 (6)

29 ± 9.60

33 ± 9.24

34 ± 10.02

29 ± 9.63

32 ± 11.29

27 ± 7.66

6 (5)

31 ± 5.37

36 ± 6.44

36 ± 6.82

31 ± 6.47

35 ± 7.82

29 ± 5.18

HR (bpm)

1 (6)

307 ± 27.11

417 ± 37.53

385 ± 22.02

389 ± 20.42

420 ± 22.31

297 ± 16.06

2 (6)

291 ± 16.65

392 ± 33.78

364 ± 18.80*

379 ± 16.73

409 ± 19.53*

297 ± 16.66

3 (6)

295 ± 12.59

393 ± 26.09*

365 ± 15.65*

377 ± 20.73*

411 ± 20.94*

295 ± 11.67

4 (6)

297 ± 25.77

401 ± 28.61

366 ± 20.41*

373 ± 21.72*

407 ± 19.90*

284 ± 12.68*

5 (6)

288 ± 17.14

387 ± 29.30*

358 ± 18.14*

366 ± 16.16*

406 ± 16.86*

291 ± 9.42

6 (5)

298 ± 18.58

386 ± 41.82

352 ± 24.35*

367 ± 7.26*

412 ± 18.68*

289 ± 13.51

BT (°C)

1 (6)

37.62 ± 0.49

37.52 ± 0.50

37.48 ± 0.52

36.50 ± 0.45

36.11 ± 0.52

37.26 ± 0.21

 

2 (6)

37.46 ± 0.43

37.43 ± 0.34

37.35 ± 0.33

36.19 ± 0.37

35.71 ± 0.41

37.25 ± 0.16

3 (6)

37.40 ± 0.37*

37.30 ± 0.28

37.20 ± 0.35

36.22 ± 0.35

35.82 ± 0.47

37.19 ± 0.32

4 (6)

37.40 ± 0.37*

37.39 ± 0.22

37.29 ± 0.24

36.32 ± 0.17

35.90 ± 0.37

37.25 ± 0.18

5 (6)

37.46 ± 0.33

37.27 ± 0.29

37.17 ± 0.38

36.16 ± 0.27

35.72 ± 0.30

37.13 ± 0.32

6 (5)

37.56 ± 0.38

37.55 ± 0.25

37.45 ± 0.26

36.20 ± 0.52*

35.71 ± 0.60*

37.20 ± 0.12

  1. *Statistical significant difference (p value ≤ 0.05) based on the ANCOVA with baseline as covariate for the comparison of anaesthetic stages between run 2–6 versus run 1.