Parameter | Units | PO Serum | PO ISF |
---|
C
max
| μg/ml | 1.89±0.83 | 0.59±0.43 |
AUC
24
| h*μg/ml | 7.42±3.03 | 5.19±4.32 |
AUC
inf
| h*μg/ml | 7.59±3.09 | 7.54±3.89 |
T
max
| h | 1.66±0.52 | 5.33±2.31 |
T
1/2
| h | 3.18±1.5 | 4.47±0.42 |
T
24
| h | 20±6.92 | 16±6.92 |
λ
z
| /h | 0.26±0.11 | 0.16±0.02 |
MRT
last
| h | 3.70±0.55 | 7.30±1.14 |
MRT
inf
| h | 4.04±0.58 | 8.25±0.79 |
- Cmax maximum concentration; AUC24 area under the curve from time 0 to 24 hours; MRTlast mean residence time; λz first order rate constant of terminal portion of the curve; T1/2 half-life; Tmax time to maximal concentration; T 24 time of final measurement; AUCinf area under the curve from 0 extrapolated to infinity; MRTinf mean residence time from time 0 extrapolated to infinity for non-infusion models.