Tissues Parameter | Dose | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
10 mg/kg | 20 mg/kg | 30 mg/kg | ||||||||||
Serum | Liver | Muscle | Kidney | Serum | Liver | Muscle | Kidney | Serum | Liver | Muscle | Kidney | |
A(μg/mL) | 0.104 | 0.172 | 0.048 | 0.118 | 0.169 | 0.435 | 0.185 | 0.21 | 0.203 | 0.687 | 0.254 | 0.453 |
A(/h) | 0.01 | 0.008 | 0.001 | 0.011 | 0.009 | 0.008 | 0.003 | 0.012 | 0.007 | 0.007 | 0.005 | 0.015 |
Ka(/h) | 0.078 | 0.249 | 0.171 | 0.202 | 0.268 | 0.222 | 0.171 | 0.214 | 0.248 | 0.217 | 0.222 | 0.211 |
Kel(/h) | 0.031 | 0.027 | 0.016 | 0.019 | 0.02 | 0.028 | 0.012 | 0.022 | 0.019 | 0.025 | 0.012 | 0.023 |
T1/2α(h) | 70.300 | 54.558 | 126.553 | 46.273 | 74.727 | 74.283 | 129.297 | 57.892 | 92.733 | 98.544 | 140.684 | 63.202 |
Tmax(h) | 6.000 | 1.000 | 48.000 | 6.000 | 1.000 | 0.500 | 10.000 | 2.000 | 0.500 | 0.500 | 4.000 | 1.000 |
Cmax(μg/mL) | 0.187 | 0.759 | 0.233 | 0.188 | 0.225 | 1.219 | 0.276 | 0.348 | 0.254 | 1.480 | 0.329 | 0.386 |
MRT0-t(h) | 61.453 | 61.61 | 60.652 | 59.982 | 64.912 | 62.200 | 71.581 | 63.192 | 69.093 | 67.674 | 73.703 | 64.946 |
AUC(μg/mL·h) | 8.392 | 17.09 | 2.704 | 7.633 | 13.516 | 29.941 | 21.380 | 12.166 | 17.665 | 55.732 | 26.675 | 18.329 |
CLs(L/kg·h) | 0.920 | 0.429 | 17.893 | 0.913 | 1.078 | 0.214 | 0.272 | 0.572 | 1.072 | 0.102 | 0.210 | 0.331 |