Skip to main content

Table 1 Haplotype and diplotype frequencies for PRNP codons 112,136, 141, 154, 171, 237 in diverse samples of U.S. sheep

From: Ovine reference materials and assays for prion genetic testing

   

Allele frequency

Codon haplotype or diplotype

  

Panel version

Breeds on panels

136

154

171

112

136

141

154

171

237

Genbank accessiona

All USMARC sheep sequencedb

V1.1

V2.0

V2.4

V2.4

Composite

Dorset

Rambouillet

Texel

Suffolk

Finnsheep

Romanov

Katahdin

All Dorper

Dorper

White Dorper

Navajo-Churro

   

(n = 953)

(n = 168)

(n = 96)

(n = 29)

(n = 18)

(n = 17)

(n = 18)

(n = 16)

(n = 19)

(n = 19)

(n = 15)

(n = 16)

(n = 8)

(n = 8)

(n = 1

ARQ

MALRQL

AY907689

0.517

0.534

0.522

0.385

0.270

0.457

0.194

0.729

0.868

0.921

0.533

0.719

0.750

0.688

0.500

ARQ

TALRQL

FJ404778

0.072

0.024

0.035

0.029

-c

0.014

-

0.021

-

-

-

-

-

-

-

ARQ

MAFRQL

FJ404776

0.009

0.002

-

-

0.008

-

-

-

-

-

-

-

-

-

-

ARQ

MAFRQP

FJ404776

0.001d

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARR

MALRRL

AY907691

0.288

0.357

0.359

0.534

0.694

0.441

0.444

0.250

0.105

0.053

0.467

0.156

-

0.313

-

ARH

MALRHL

AY907683

0.017

0.027

0.042

-

-

-

0.250

-

-

-

-

-

-

-

-

AHQ

MALHQL

AY909542

0.009

0.024

0.016

-

0.028

0.088

0.111

-

-

-

-

-

-

-

-

VRQ

MVLRQL

AY907685

0.035

0.027

0.021

0.052

-

-

-

-

0.026

0.026

-

0.125

0.250

-

-

ARK

MALRKL

EF189728

0.054

0.006

0.005

-

-

-

-

-

-

-

-

-

-

-

0.500

TRQd

MTLRQLe

AJ567987

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MALRQL, MALRQL

AY907689

0.300

0.333

0.333

0.172

0.056

0.235

-

0.313

0.737

0.842

0.200

0.500

0.500

0.500

-

ARQ, ARQ

MALRQL, TALRQL

FJ404777

0.069

0.030

0.021

0.069

-

-

-

0.188

-

-

-

-

-

-

-

ARQ, ARQ

TALRQL, TALRQL

FJ404778

0.014

0.006

0.010

-

-

-

-

0.063

-

-

-

-

-

-

-

ARQ, ARQ

MALRQL, MAFRQL

EF189724

0.004

0.006

-

-

0.056

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MAFRQL, MAFRQL

naf

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MALRQL, MAFRQP

na

0.001d

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MAFRQL, MAFRQP

FJ404776

0.008d

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MAFRQP, MAFRQP

na

0.001d

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MAFRQL, TALRQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARQ

MAFRQP, TALRQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARR

MALRQL, MALRRL

AY907684

0.254

0.262

0.271

0.276

0.333

0.412

0.111

0.125

0.211

0.105

0.667

0.188

-

0.375

-

ARQ, ARR

TALRQL, MALRRL

FJ404777

0.046

0.030

0.021

-

-

0.059

-

0.250

-

-

-

-

-

-

-

ARQ, ARR

MAFRQL, MALRRL

na

0.011

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARR

MAFRQP, MALRRL

na

0.003d

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARH

MALRQL, MALRHL

AY907693

0.015

0.024

0.042

-

-

-

0.222

-

-

-

-

-

-

-

-

ARQ, ARH

TALRQL, MALRHL

na

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARH

MAFRQL, MALRHL

na

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARH

MAFRQP, MALRHL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, AHQ

MALRQL, MALHQL

AY907687

0.002

0.006

0.010

-

-

-

0.056

-

-

-

-

-

-

-

-

ARQ, AHQ

TALRQL, MALHQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, AHQ

MAFRQL, MALHQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, AHQ

MAFRQP, MALHQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, VRQ

MALRQL, MVLRQL

AY907690

0.029

0.042

0.031

0.034

-

-

-

-

0.053

0.053

-

0.250

0.500

-

-

ARQ, VRQ

TALRQL, MVLRQL

FJ404777

-

0.006

-

0.034

-

-

-

-

-

-

-

-

-

-

-

ARQ, VRQ

MAFRQL, MVLRQL

na

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, VRQ

MAFRQP, MVLRQL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARK

MALRQL, MALRKL

EF189727

0.037

0.006

0.010

-

-

-

-

-

-

-

-

-

-

-

1.000

ARQ, ARK

TALRQL, MALRKL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARK

MAFRQL, MALRKL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARQ, ARK

MAFRQP, MALRKL

na

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARR, ARR

MALRRL, MALRRL

AY907691

0.103

0.185

0.188

0.379

0.500

0.176

0.222

0.063

-

-

0.133

0.063

-

0.125

-

ARR, ARH

MALRRL, MALRHL

AY907681

0.005

0.018

0.021

-

-

-

0.167

-

-

-

-

-

-

-

-

ARR, AHQ

MALRRL, MALHQL

AY907682

0.008

0.030

0.021

-

0.056

0.059

0.167

-

-

-

-

-

-

-

-

ARR, VRQ

MALRRL, MVLRQL

AY907688

0.020

0.006

0.010

0.034

0.000

-

-

-

-

-

-

-

-

-

-

ARR, ARK

MALRRL, MALRKL

EF189729

0.026

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARH, ARH

MALRHL, MALRHL

AY907683

0.001

0.006

0.010

-

-

-

0.056

-

-

-

-

-

-

-

-

ARH, AHQ

MALRHL, MALHQL

AY907692

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARH, VRQ

MALRHL, MVLRQL

AY907694

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARH, ARK

MALRHL, MALRKL

EF189726

0.007

-

-

-

-

-

-

-

-

-

-

-

-

-

-

AHQ, AHQ

MALHQL, MALHQL

AY909542

0.001

0.006

-

-

-

0.059

-

-

-

-

-

-

-

-

-

AHQ, VRQ

MALHQL, MVLRQL

AY907686

0.001

-

-

-

-

-

-

-

-

-

-

-

-

-

-

AHQ, ARK

MALHQL, MALRKL

EF189725

0.004

-

-

-

-

-

-

-

-

-

-

-

-

-

-

VRQ, VRQ

MVLRQL, MVLRQL

AY907685

0.004

-

-

-

-

-

-

-

-

-

-

-

-

-

-

VRQ, ARK

MVLRQL, MALRKL

EF189722

0.008

-

-

-

-

-

-

-

-

-

-

-

-

-

-

ARK, ARK

MALRKL, MALRKL

EF189728

0.012

-

-

-

-

-

-

-

-

-

-

-

-

-

-

  1. aGenBank accession numbers for sequences from control animals on MSCP27 with the relavant diplotype (where available).
  2. bSheep born 1995 to 2007. Allele or genotype frequencies that add up to 0.999 or 1.001 are the result of rounding errors.
  3. cNo minor alleles detected
  4. dSheep with 237P allele are descendents of a single composite ram
  5. eNot present in U.S. populations surveyed. GenBank accession number correspends to Billinis et al. 2004. J. Gen. Virol. 85, 547-554
  6. fNot available
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us