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Oncology

The oncology section considers research that addresses the etiology and treatment of cancer in veterinary patients. Research describing cancer prevention, therapeutic strategies, molecular diagnostics, genetics and genomics, epidemiology and comparative oncology are encouraged. Comparative and translational studies are also considered. 

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  1. Domestic cats rarely develop hepatocellular carcinoma. The reason for the low prevalence is unknown. Reductions in hepatocellular ploidy have been associated with hepatic carcinogenesis. Recent work in mice ha...

    Authors: Jacqueline Post, Ingeborg M. Langohr, Cynthia R.L. Webster, Peter Mottram, Chin-Chi Liu and Andrea Johnston

    Citation: BMC Veterinary Research 2021 17:104

    Content type: Research article

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  2. Doxorubicin (DOX) is widely used in both human and veterinary oncology although the onset of multidrug resistance (MDR) in neoplastic cells often leads to chemotherapy failure. Better understanding of the cell...

    Authors: Michela Levi, Roberta Salaroli, Federico Parenti, Raffaella De Maria, Augusta Zannoni, Chiara Bernardini, Cecilia Gola, Antonio Brocco, Asia Marangio, Cinzia Benazzi, Luisa Vera Muscatello, Barbara Brunetti, Monica Forni and Giuseppe Sarli

    Citation: BMC Veterinary Research 2021 17:30

    Content type: Research article

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  3. Squamous Cell Carcinoma of horn, also known as horn cancer, is a prevailing type of cancer in cattles especially Bos indicus. It is one of the most prevalent disease in Indian bullocks often resulting in death an...

    Authors: Dhruv Bhatia, Ankit Hinsu, Ketankumar Panchal, Pritesh Sabara, Subhash Jakhesara and Prakash Koringa

    Citation: BMC Veterinary Research 2020 16:461

    Content type: Research article

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  4. Teratomas are germ cell neoplasms composed of a wide variety of tissues. In the woodchuck, only one testicular teratoma has been described in the literature. The objective of this report was to describe the ra...

    Authors: Johnathan Zeng, Matthew F. Starost, Michal Mauda-Havakuk, Andrew S. Mikhail, Ari Partanen, Bradford J. Wood, John W. Karanian and William F. Pritchard

    Citation: BMC Veterinary Research 2020 16:451

    Content type: Case Report

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  5. Canine hemangiosarcoma (HSA) is an aggressive cancer arising from multipotential bone marrow-derived stem cells. Anthracycline chemotherapy drugs have been the mainstay adjuvant chemotherapy following surgery ...

    Authors: Michael D. Lucroy, Ryan M. Clauson, Mark A. Suckow, Ferris El-Tayyeb and Ashley Kalinauskas

    Citation: BMC Veterinary Research 2020 16:447

    Content type: Research article

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  6. The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a ke...

    Authors: Rebecca Makii, Hanna Cook, Darian Louke, Justin Breitbach, Ryan Jennings, Christopher Premanandan, Eric M. Green and Joelle M. Fenger

    Citation: BMC Veterinary Research 2020 16:415

    Content type: Research article

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  7. Reports of osteoblastic tumours are limited to a few case reports in veterinary medicine. Osteoblastoma-like osteosarcoma has been accepted by the World Health Organization as an intermediate form between an o...

    Authors: Felix Giebels, Franck Forterre, Simona Vincenti, Urs Geissbuehler, Monika M. Welle, Roy Pool, Sabina Soldati and Arianna Maiolini

    Citation: BMC Veterinary Research 2020 16:378

    Content type: Case Report

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  8. Various types of oral tumors, either benign or malignant, are commonly found in dogs. Since saliva directly contacts the tumors and saliva collection is non-invasive, easily accessible and cost effective, sali...

    Authors: Sekkarin Ploypetch, Sittiruk Roytrakul, Narumon Phaonakrop, Suthathip Kittisenachai, Kantinan Leetanasaksakul, Sirinun Pisamai, Chanin Kalpravidh, Anudep Rungsipipat and Gunnaporn Suriyaphol

    Citation: BMC Veterinary Research 2020 16:335

    Content type: Research article

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  9. Intraosseous epidermoid cyst (IEC) is a rare, non-neoplastic, pathology in animals and humans that most commonly affects the distal phalanx. In dogs, it is important to differentiate this lesion from malignant...

    Authors: Michail Vagias, Joseph P. Cassidy, Cliona Skelly and Ronan A. Mullins

    Citation: BMC Veterinary Research 2020 16:323

    Content type: Case Report

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  10. Cancer is a leading cause of mortality for both humans and dogs. As spontaneous canine cancers appear to be relevant models of human cancers, developing new therapeutic approaches could benefit both species. O...

    Authors: Jérémy Béguin, Virginie Nourtier, Murielle Gantzer, Sandrine Cochin, Johann Foloppe, Jean-Marc Balloul, Eve Laloy, Dominique Tierny, Bernard Klonjkowski, Eric Quemeneur, Christelle Maurey and Philippe Erbs

    Citation: BMC Veterinary Research 2020 16:307

    Content type: Research article

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  11. Marek’s disease (MD) is a chicken neoplastic disease, which brings huge economic losses to the global poultry industry. The wild type p53, a tumor suppressor gene, plays a key role in blocking cell cycle, prom...

    Authors: Huixia Zhang, Mengda Liu, Hui Zhang, Shengliang Cao, Yue Li, Shengnan Jiang, Yinuo Song and Sidang Liu

    Citation: BMC Veterinary Research 2020 16:303

    Content type: Research article

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  12. Ovine pulmonary adenocarcinoma (OPA) is a neoplastic disease caused by exogenous Jaagsiekte Sheep Retrovirus (exJSRV). The prevalence of JSRV-related OPA in Eastern European countries, including Romania is unk...

    Authors: Corina Toma, Valentin Adrian Bâlteanu, Septiumiu Tripon, Adrian Trifa, Alexandra Rema, Irina Amorim, Raluca Maria Pop, Roxana Popa, Cornel Catoi and Marian Taulescu

    Citation: BMC Veterinary Research 2020 16:296

    Content type: Research article

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  13. p53 protein is essential for the regulation of cell proliferation. Aberrant accumulation of it usually occurs in cutaneous malignancies. Mutant p53 is detected by immunohistochemistry because it is more stable...

    Authors: María José García-Iglesias, Jose Luis Cuevas-Higuera, Ana Bastida-Sáenz, María Gracia de Garnica-García, Laura Polledo, Paula Perero, Jorge González-Fernández, Beatriz Fernández-Martínez and Claudia Pérez-Martínez

    Citation: BMC Veterinary Research 2020 16:239

    Content type: Research article

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  14. Chronic inflammation mediated by the cyclooxygenase enzymes, specifically their product prostaglandin E2 (PGE2), can result in the development of cancer. PGE2 promotes cell proliferation, apoptosis, and angiog...

    Authors: Margaret L. Musser, Austin K. Viall, Rachel L. Phillips, Jesse M. Hostetter and Chad M. Johannes

    Citation: BMC Veterinary Research 2020 16:213

    Content type: Research article

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  15. Canine visceral hemangiosarcoma (HSA) is a highly aggressive cancer of endothelial origin that closely resembles visceral angiosarcoma in humans, both clinically and histopathologically. Currently there is an ...

    Authors: Chinatsu Mukai, Eunju Choi, Kelly L. Sams, Elena Zu Klampen, Lynne Anguish, Brooke A. Marks, Edward J. Rice, Zhong Wang, Lauren A. Choate, Shao-Pei Chou, Yukinari Kato, Andrew D. Miller, Charles G. Danko and Scott A. Coonrod

    Citation: BMC Veterinary Research 2020 16:206

    Content type: Research article

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  16. Canine mammary gland tumors (cMGTs) are the most common neoplasms in intact female canines and viewed as a suitable model for studying human breast cancers. Euphorbia royleana has been reported to have a variety ...

    Authors: Yu-Ya Huang, Chia-Hung Chen, Chia-Hui Hsu, Tsun-Yung Kuo, Cheng-Chi Liu, Albert Tai-Ching Liao and Chen-Si Lin

    Citation: BMC Veterinary Research 2020 16:193

    Content type: Research article

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  17. Additive manufacturing has allowed for the creation of a patient-specific custom solution that can resolve many of the limitations previously reported for canine cranioplasty. The purpose of this pilot study w...

    Authors: J. James, M. L. Oblak, A. R. zur Linden, F. M. K. James, J. Phillips and M. Parkes

    Citation: BMC Veterinary Research 2020 16:180

    Content type: Methodology article

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  18. The microenvironment within solid malignant tumors, including feline mammary gland carcinomas (FMGCs), is commonly hypoxic, possibly due to the lack of functional blood vessels in rapidly proliferating neoplas...

    Authors: Bo Chen, Susanne Je-Han Lin, Wen-Ta Li, Hui-Wen Chang, Victor Fei Pang, Pei-Yi Chu, Chin-Cheng Lee, Hiroyuki Nakayama, Ching-Ho Wu and Chian-Ren Jeng

    Citation: BMC Veterinary Research 2020 16:125

    Content type: Research article

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  19. Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured, and median survival times are generally in the 12-month range. Novel approaches to treatmen...

    Authors: Douglas H. Thamm, Jenette K. Joseph, Barbara J. Rose, Travis K. Meuten and Kristen M. Weishaar

    Citation: BMC Veterinary Research 2020 16:97

    Content type: Research article

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  20. Gain-of-function mutations in KIT are driver events of oncogenesis in mast cell tumours (MCTs) affecting companion animals. Somatic mutations of KIT determine the constitutive activation of the tyrosine kinase...

    Authors: Fabio Gentilini, Maria Elena Turba, Claire Dally, Masamine Takanosu, Sena Kurita and Makoto Bonkobara

    Citation: BMC Veterinary Research 2020 16:64

    Content type: Case Report

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  21. Dogs develop cancer spontaneously with age, with breed-specific risk underlying differences in genetics. Mammary tumors are reported as the most frequent neoplasia in intact female dogs. Their high prevalence ...

    Authors: Pauline Thumser-Henner, Katarzyna J. Nytko and Carla Rohrer Bley

    Citation: BMC Veterinary Research 2020 16:30

    Content type: Review

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  22. The epidermal growth factor receptors participate in the physiological processes such as regulation of morphogenesis, proliferation and cell migration, but when overexpressed or overactivated they may play an ...

    Authors: Emerson Soares Veloso, Ivy Nayra Nascimento Gonçalves, Tatiany Luiza Silveira, Fernando Soares Oliveira, Déborah Soares Vieira, Geovanni Dantas Cassali, Helen Lima Del Puerto and Enio Ferreira

    Citation: BMC Veterinary Research 2020 16:24

    Content type: Research article

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  23. Pheochromocytoma (PCC) has poor prognosis and adrenalectomy is hard to be performed, in case of caudal vena cava invasion. The long-term administration of phenoxybenzamine in PCC has not been reported in dogs.

    Authors: Ga-Won Lee, Cho-Rong Yoo, Dan Lee and Hee-Myung Park

    Citation: BMC Veterinary Research 2020 16:3

    Content type: Case Report

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  24. Listeria monocytogenes is a promising therapeutic vaccine vector for cancer immunotherapy. Although highly attenuated, three cases of systemic listeriosis have been reported in people following treatment with Lis...

    Authors: Margaret L. Musser, Erika P. Berger, Cameron Parsons, Sophia Kathariou and Chad M. Johannes

    Citation: BMC Veterinary Research 2019 15:467

    Content type: Case Report

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  25. Peritoneal mesothelioma is a rare abdominal disease; that occasionally occurs congenitally in younger calves. Cytologic examination of peritoneal effusion (PE) was utilized to diagnose this disease, and was no...

    Authors: Yasuhiro Morita, Sadamu Sugiyama, Takeshi Tsuka, Yoshiharu Okamoto, Takehito Morita, Yuji Sunden and Takashi Takeuchi

    Citation: BMC Veterinary Research 2019 15:461

    Content type: Case Report

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  26. Assessment of the efficacy of a multi-agent chemotherapy protocol in which cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) are administered in canine lymphoma is generally performed by physica...

    Authors: Amadeo M. Parissenti, Laura B. Pritzker, Baoqing Guo, Rashmi Narendrula, Shirly Xiaohui Wang, Lin Laura Lin, Jingchun Pei, Karolina Skowronski, Dorothee Bienzle, J. Paul Woods, Kenneth P. H. Pritzker and Brenda L. Coomber

    Citation: BMC Veterinary Research 2019 15:453

    Content type: Research article

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  27. Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios ...

    Authors: Arata Matsuyama, Dorothee Bienzle, Danielle Richardson, Nariman Deravi, Mei-Hua Hwang, Nikos Darzentas and Stefan M. Keller

    Citation: BMC Veterinary Research 2019 15:413

    Content type: Case Report

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  28. Total skin electron beam radiation therapy (TSEBT) is an effective treatment for primary diffuse cutaneous lymphomas in humans. While several techniques exist, they all require significant commitment of staff ...

    Authors: Michael A. Deveau, Megan Sutton, Courtney Baetge and Alison B. Diesel

    Citation: BMC Veterinary Research 2019 15:407

    Content type: Case Report

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  29. Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas...

    Authors: Keidylania Costa-Santos, Karine Damasceno, Ricardo Dias Portela, Ferlando Lima Santos, Genira Carneiro Araújo, Emanoel Ferreira Martins-Filho, Laís Pereira Silva, Thiago Doria Barral, Stefanie Alvarenga Santos and Alessandra Estrela-Lima

    Citation: BMC Veterinary Research 2019 15:401

    Content type: Research article

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  30. Mammary cancer is a common disease affecting female dogs, where approximately 50% of the cases are malignant. There is a subpopulation of cancer cells with stem cell-like features within the tumour microenviro...

    Authors: Consuelo Serrano, Sofía Guzmán, Jose Ignacio Arias and Cristian Gabriel Torres

    Citation: BMC Veterinary Research 2019 15:390

    Content type: Research article

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  31. Chronic inflammation has been implicated in sarcomagenesis. Among various factors, activation of nuclear factor-kappa B (NF-κB) signaling pathway has been documented being able to target genes associated with ...

    Authors: Cheng-Shun Hsueh, Ching-Ho Wu, Cheng-Hsin Shih, Jason Lih-Seng Yeh, Chian-Ren Jeng, Victor Fei Pang, Hue-Ying Chiou and Hui-Wen Chang

    Citation: BMC Veterinary Research 2019 15:365

    Content type: Research article

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  32. Canine and human osteosarcomas (OS) are notably similar and have a high rate of metastasis. There is a poor understanding of the tumor development process, predisposing causes, and varying levels of aggression...

    Authors: Heather Wilson-Robles, Kelli Franks, Roy Pool and Tasha Miller

    Citation: BMC Veterinary Research 2019 15:357

    Content type: Research article

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  33. Estrogens are essential for the development and proper function of several hormone-dependent organs. There are, however, several lines of evidence associating estrogens with mammary carcinogenesis. A marked in...

    Authors: Ana Canadas-Sousa, Marta Santos, Bárbara Leal, Rui Medeiros and Patrícia Dias-Pereira

    Citation: BMC Veterinary Research 2019 15:325

    Content type: Research article

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  34. Oclacitinib is an orally bioavailable Janus Kinase (JAK) inhibitor approved for the treatment of canine atopic dermatitis. Aberrant JAK/ Signal Transducer and Activator of Transcription (STAT) signaling within...

    Authors: Laura E. Barrett, Heather L. Gardner, Lisa G. Barber, Abbey Sadowski and Cheryl A. London

    Citation: BMC Veterinary Research 2019 15:291

    Content type: Research article

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  35. Mammary gland tumor is the most common spontaneous tumor in intact female dogs, and its poor prognosis remains a clinical challenge. Ivermectin, a well-known anti-parasitic agent, has been implicated as a pote...

    Authors: Hongxiu Diao, Nan Cheng, Ying Zhao, Huihao Xu, Haodi Dong, Douglas H. Thamm, Di Zhang and Degui Lin

    Citation: BMC Veterinary Research 2019 15:276

    Content type: Research article

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  36. Thyroid neoplasia is a common endocrine neoplasm in dogs. The boxer is one of the reported breeds predisposed to malignant thyroid neoplasia. However, the association between thyroid neoplasia, malignancy and ...

    Authors: Marie-Pauline Maurin, Dan Davies, Hanne Jahns, Robert E. Shiel and Carmel T. Mooney

    Citation: BMC Veterinary Research 2019 15:228

    Content type: Case Report

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  37. Myxosarcomas are known to be classified as soft tissue sarcomas. However, there is limited clinical characterization pertaining specifically to canine cutaneous myxosarcomas in the literature. The objective of...

    Authors: Yoshimi Iwaki, Stephanie Lindley, Annette Smith, Kaitlin M. Curran and Jayme Looper

    Citation: BMC Veterinary Research 2019 15:217

    Content type: Research article

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  38. Mast cell tumours are the most common cutaneous neoplasms in dogs. Other primary sites include visceral organs, such as the gastrointestinal tract, liver, or spleen, and the oral cavity. Frequent metastatic sites...

    Authors: Juan Carlos Cartagena-Albertus, Antoaneta Moise, Sergio Moya-García, Nora Cámara-Fernández and Jose Alberto Montoya-Alonso

    Citation: BMC Veterinary Research 2019 15:204

    Content type: Case Report

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  39. Sphingosine kinase 1 (SPHK1) is an enzyme that converts pro-apoptotic ceramide and sphingosine into anti-apoptotic sphingosine-1-phosphate. There is growing evidence that SPHK1 activation promotes oncogenic tr...

    Authors: Yi-Chih Chang, Hsiao-Li Chuang, Ji-Hang Yin, Jiunn-Wang Liao, Ter-Hsin Chen and Yu-Chih Wang

    Citation: BMC Veterinary Research 2019 15:155

    Content type: Research article

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  40. This report describes a case of a bronchiolar adenocarcinoma in a 6-year old alpaca mare. For the first time in an alpaca, neoplasia was classified by histopathology as a lepidic-predominant bronchiolar adenoc...

    Authors: Lara Moser, Kristel Kegler, Christina Precht and Patrik Zanolari

    Citation: BMC Veterinary Research 2019 15:139

    Content type: Case Report

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  41. Dogs with appendicular osteosarcoma (OSA) receiving standard amputation and adjuvant chemotherapy demonstrate variable outcome with treatment; however, additional biomarkers would be helpful for predicting the...

    Authors: Kazuki Heishima, Travis Meuten, Kyoko Yoshida, Takashi Mori and Douglas H. Thamm

    Citation: BMC Veterinary Research 2019 15:39

    Content type: Research article

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  42. Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpos...

    Authors: Lucia Borlle, Abdo Dergham, Zacharie Wund, Brittany Zumbo, Teresa Southard and Kelly R. Hume

    Citation: BMC Veterinary Research 2019 15:36

    Content type: Research article

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  43. Cats spontaneously develop invasive mammary carcinomas with high clinical aggressiveness, and are considered relevant animal models for human breast cancer. Bcl-2 is an anti-apoptotic pro-survival protein, who...

    Authors: Elie Dagher, Jérôme Abadie, Delphine Loussouarn, Dominique Fanuel, Mario Campone and Frédérique Nguyen

    Citation: BMC Veterinary Research 2019 15:25

    Content type: Research article

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  44. Osteosarcoma (OSA) is the most common bone cancer in canines. Both transforming growth factor beta (TGFβ) and Hippo pathway mediators have important roles in bone development, stemness, and cancer progression....

    Authors: Anita K. Luu, Courtney R. Schott, Robert Jones, Andrew C. Poon, Brandon Golding, Roa’a Hamed, Benjamin Deheshi, Anthony Mutsaers, Geoffrey A. Wood and Alicia M. Viloria-Petit

    Citation: BMC Veterinary Research 2018 14:365

    Content type: Research article

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  45. A doxorubicin (DOX)-based chemotherapy protocol, CHOP, is the most effective treatment for canine high-grade B-cell lymphoma; however, the cost and time requirements associated with this protocol are not feasi...

    Authors: Sami Al-Nadaf, Robert B. Rebhun, Kaitlin M. Curran, Rachel O. Venable, Katherine A. Skorupski, Jennifer L. Willcox and Jenna H. Burton

    Citation: BMC Veterinary Research 2018 14:356

    Content type: Research article

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  46. Objective of this study is a feasibility-test comparing hock- and footpad-injection in rats with inoculated MatLyLu - adenocarcinoma tumor model. This study compares the development of an adenocarcinoma model ...

    Authors: Henning Richter, Agnieszka Karol, Katja Nuss, Aymone Lenisa, Erika Bruellmann, Stella-Saphira Maudens, Heinrich Hoffmann, Brigitte von Rechenberg and Patrick R. Kircher

    Citation: BMC Veterinary Research 2018 14:327

    Content type: Research article

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  47. Melanomas are rare in cats. The eye is the most commonly involved site, whereas few data are available about feline non-ocular melanomas (NOMs). Ki-67 thresholds with prognostic relevance have been established...

    Authors: Silvia Sabattini, Andrea Renzi, Francesco Albanese, Marco Fantinati, Antonella Rigillo, Francesca Abramo, Raimondo Tornago, Giovanni Tortorella, Maria Massaro, Teresa Bruna Pagano, Julia Buchholz and Giuliano Bettini

    Citation: BMC Veterinary Research 2018 14:309

    Content type: Research article

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