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Neurology and neuroscience

The neurology and neuroscience section combines all aspects of this specialty into a single section, and also includes those aspects of neurology and neurosurgery that overlap with other disciplines, such as internal medicine, surgery, imaging, and pathology. This section encourages high-quality submissions of basic and clinical research on the anatomy, development, and physiology of the nervous system as well as all aspects of clinical neurology, including the development, prevention, diagnosis and treatment of diseases of the central and peripheral nervous system, including muscular diseases. Comparative and translational studies relevant to the central or peripheral nervous system of all domestic and non-domestic species are considered. 
 

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  1. Objective outcome measures capable of tracking different aspects of functional recovery in dogs with acute intervertebral disc herniation are needed to optimize physical rehabilitation protocols. Normal, pre-i...

    Authors: Jessica E. Linder, Stephanie Thomovsky, Jessica Bowditch, Mallory Lind, Kristine A. Kazmierczak, Gert J. Breur and Melissa J. Lewis

    Citation: BMC Veterinary Research 2021 17:110

    Content type: Research article

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  2. Status epilepticus (SE) or prolonged epileptic seizure activity is a common neurological emergency with a high mortality rate and, if left untreated, can lead to irreversible cerebral damage and systemic compl...

    Authors: Marios Charalambous, Holger A. Volk, Luc Van Ham and Sofie F. M. Bhatti

    Citation: BMC Veterinary Research 2021 17:103

    Content type: Review

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  3. Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative disorder found in senior dogs. Due to the lack of biological markers, CCDS is commonly underdiagnosed. The aim of this study was ...

    Authors: Sataporn Phochantachinda, Boonrat Chantong, Onrapak Reamtong and Duangthip Chatchaisak

    Citation: BMC Veterinary Research 2021 17:60

    Content type: Research article

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  4. Aquaporin-4 (AQP4) is in growing recognition as potential marker for cancer progression, differentiation and therapeutic intervention. No information is available about AQP4 expression in the normal canine bra...

    Authors: Patricia Álvarez, Ester Blasco, Martí Pumarola and Annette Wessmann

    Citation: BMC Veterinary Research 2021 17:29

    Content type: Research article

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  5. Because of fast leucocyte degeneration in cerebrospinal fluid (CSF) laboratory examinations of CSF samples should be performed approximately within 30 min after withdrawal. This study examines the storage of c...

    Authors: Laura Meier, Regina Carlson, Jasmin Neßler and Andrea Tipold

    Citation: BMC Veterinary Research 2020 16:487

    Content type: Research article

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  6. Progressive myelomalacia (PMM) is a fatal complication of progressive ascending and descending necrosis of the spinal cord after acute spinal cord injury. A recent study suggested that extensive hemilaminectom...

    Authors: Ryuji Hirano, Ryota Asahina, Taiyo Hirano, Ayuko Hyakkoku, Rino Miura, Takuya Kunihiro and Yuya Nakamoto

    Citation: BMC Veterinary Research 2020 16:476

    Content type: Research article

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  7. Idiopathic epilepsy is a common neurological condition in dogs. Previous research has focused on clinical aspects of seizure management in dogs with idiopathic epilepsy with little attention given to the emoti...

    Authors: Amy E. Pergande, Zoe Belshaw, Holger A. Volk and Rowena M. A. Packer

    Citation: BMC Veterinary Research 2020 16:443

    Content type: Research article

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  8. Osteomyelitis is relatively frequent in young pigs and a few bacterial species have been postulated to be potential causative agents. Although Actinobacillus (A.) pleuropneumoniae has been sporadically described ...

    Authors: Felix Giebels, Urs Geissbühler, Anna Oevermann, Alexander Grahofer, Philipp Olias, Peter Kuhnert, Arianna Maiolini and Veronika Maria Stein

    Citation: BMC Veterinary Research 2020 16:438

    Content type: Case Report

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  9. Radiotherapy (RT) is currently considered the treatment of choice for presumed canine intracranial gliomas. However, variable therapeutic responses are described, due to heterogeneous populations and different...

    Authors: M. Debreuque, P. De Fornel, I. David, F. Delisle, M. N. Ducerveau, P. Devauchelle and J. L. Thibaud

    Citation: BMC Veterinary Research 2020 16:412

    Content type: Research article

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  10. This case report describes the clinical signs of a calf with focal diplomyelia at the level of the fourth lumbar vertebra. Magnetic resonance imaging (MRI) images and histological findings of the affected spin...

    Authors: Gerlinde J. Wunderink, Ursula E. A. Bergwerff, Victoria R. Vos, Mark W. Delany, Dorien S. Willems and Peter R. Hut

    Citation: BMC Veterinary Research 2020 16:398

    Content type: Case Report

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  11. Transmissible mink encephalopathy (TME) is a fatal neurologic disease of farmed mink. Evidence indicates that TME and L-BSE are similar and may be linked in some outbreaks of TME. We previously transmitted bov...

    Authors: Eric Cassmann, Sarah Jo Moore, Robyn Kokemuller, Anne Balkema-Buschmann, Martin Groschup, Eric Nicholson and Justin Greenlee

    Citation: BMC Veterinary Research 2020 16:383

    Content type: Research article

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  12. With evidence of warming climates, it is important to understand the effects of heat stress in farm animals in order to minimize production losses. Studying the changes in the brain proteome induced by heat st...

    Authors: Tian-yue Yu, Yan-hong Yong, Jun-yu Li, Biao Fang, Can-ying Hu, Lian-yun Wu, Xiaoxi Liu, Zhichao Yu, Xingbin Ma, Yadnyavalkya Patil, Ravi Gooneratne and Xiang-hong Ju

    Citation: BMC Veterinary Research 2020 16:286

    Content type: Research article

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  13. A negative potential is occasionally recorded in humans and animals with profound deafness during brainstem auditory evoked potential (BAER) tests if loud intensities are used. This acoustically evoked short l...

    Authors: Ezio Bianchi, Anna Maria Cantoni and Luc Poncelet

    Citation: BMC Veterinary Research 2020 16:215

    Content type: Case Report

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  14. Combination therapy with glucocorticoids and adjunctive immunomodulating drugs has been generally accepted as a standard treatment regimen for meningoencephalomyelitis of unknown etiology (MUE). We hypothesize...

    Authors: Joong-Hyun Song, Do-Hyeon Yu, Hee-Chun Lee, Tae-Sung Hwang, Young Joo Kim, Su-Jin An and Dong-In Jung

    Citation: BMC Veterinary Research 2020 16:192

    Content type: Research article

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  15. Vestibular dysfunction is relatively common in dogs, with a prevalence of 0.08% reported in primary veterinary care in the UK. There are several studies investigating how to differentiate between peripheral an...

    Authors: Rocio Orlandi, Rodrigo Gutierrez-Quintana, Beatrice Carletti, Camilla Cooper, Josep Brocal, Sara Silva and Rita Gonçalves

    Citation: BMC Veterinary Research 2020 16:159

    Content type: Research article

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  16. Perfusion-weighted imaging is only scarcely used in veterinary medicine. The exact reasons are unclear. One reason might be the typically high costs of the software packages for image analysis. In addition, a ...

    Authors: Antje Hartmann, Volkher B. Scholz and Ines E. Lautenschläger

    Citation: BMC Veterinary Research 2020 16:141

    Content type: Software

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  17. Medical infrared thermal imaging (MITI) is a non-invasive imaging modality gaining popularity in the veterinary field. An infrared camera captures emission of heat and creates a color map in the form of a ther...

    Authors: M. Larkin, C. Loughin, D. Marino, C. Dewey, S. Umbaugh and J. Sackman

    Citation: BMC Veterinary Research 2020 16:137

    Content type: Research article

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  18. Recent studies have reported contrasting results of the effects of laser therapy on post-operative intervertebral disk herniation, with a lack of evidence-based advantages of this modality within a rehabilitat...

    Authors: Enrico Bruno, Sara Canal, Michela Antonucci, Marco Bernardini, Federica Balducci, Vincenzo Musella, Matteo Mussoni and Giuseppe Spinella

    Citation: BMC Veterinary Research 2020 16:120

    Content type: Research article

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  19. Syringomyelia (SM) is a debilitating condition in the cavalier King Charles spaniel (CKCS) that results in neuropathic pain and diminished quality of life. Von Frey aesthesiometry (VFA) is a method of mechanic...

    Authors: Ashley C. Hechler, Eric T. Hostnik, Laurie B. Cook, Lynette K. Cole and Sarah A. Moore

    Citation: BMC Veterinary Research 2020 16:94

    Content type: Research article

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  20. Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor. However, there is an ap...

    Authors: Eva-Lotta von Rüden, Fabio Gualtieri, Katharina Schönhoff, Maria Reiber, Fabio Wolf, Wolfgang Baumgärtner, Florian Hansmann, Andrea Tipold and Heidrun Potschka

    Citation: BMC Veterinary Research 2020 16:18

    Content type: Research article

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  21. Positron emission tomography (PET) is increasingly being used as an imaging modality for clinical and research applications in veterinary medicine. Amyloid PET has become a useful tool for diagnosing Alzheimer...

    Authors: Taesik Yun, Wonguk Lee, Ji-Houn Kang, Mhan-Pyo Yang and Byeong-Teck Kang

    Citation: BMC Veterinary Research 2020 16:17

    Content type: Research article

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  22. Inflammatory pseudotumours (IPTs) are distinctive lesions consisting of myofibroblastic spindle cells and a variety of inflammatory cells. The aetiology of IPTs is unknown. Reports of IPTs in veterinary medici...

    Authors: Masamichi Yamashita, Tomohiro Osaki, Yusuke Murahata, Yuji Sunden, Rinko Morita, Tomohiro Imagawa and Yoshiharu Okamoto

    Citation: BMC Veterinary Research 2019 15:459

    Content type: Case Report

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  23. Progressive myelomalacia (PMM) is a usually fatal complication of acute intervertebral disc extrusion (IVDE) in dogs but its risk factors are poorly understood. The objective of this retrospective case-control...

    Authors: Aude Castel, Natasha J. Olby, Hongyu Ru, Christopher L. Mariani, Karen R. Muñana and Peter J. Early

    Citation: BMC Veterinary Research 2019 15:433

    Content type: Research article

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  24. Infectious canine hepatitis is a rarely encountered disease, that is caused by Canine Adenovirus-1. Clinical signs can vary dramatically, and neurological signs are rarely seen. Neurological manifestation of t...

    Authors: Samuel J. Hornsey, Hélène Philibert, Dale L. Godson and Elisabeth C. R. Snead

    Citation: BMC Veterinary Research 2019 15:418

    Content type: Case Report

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  25. Currently, [18F] altanserin is the most frequently used PET-radioligand for serotonin2A (5-HT2A) receptor imaging in the human brain but has never been validated in dogs. In vivo imaging of this receptor in the c...

    Authors: Glenn Pauwelyn, Lise Vlerick, Robrecht Dockx, Jeroen Verhoeven, Andre Dobbeleir, Tim Bosmans, Kathelijne Peremans, Christian Vanhove, Ingeborgh Polis and Filip De Vos

    Citation: BMC Veterinary Research 2019 15:415

    Content type: Research article

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  26. Transport stress not only causes physiological changes but also induces behavioral responses, including anxiety-like and depression-like behavioral responses in animals. The neuronal nitric oxide synthase (nNO...

    Authors: Jia Wang, Jiao Li, Mingyuan Yu, Yuying Wang and Yunfei Ma

    Citation: BMC Veterinary Research 2019 15:323

    Content type: Research article

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  27. The split spinal cord malformation (SSCM) is an uncommon congenital malformation of the vertebral canal in which parts of the spinal cord are longitudinally duplicated. In SSCM Type I, each spinal cord has its...

    Authors: Lara Górriz-Martín, Jasmin Neßler, Iris Voelker, Sina Reinartz, Andrea Tipold, Ottmar Distl, Andreas Beineke, Juergen Rehage and Maike Heppelmann

    Citation: BMC Veterinary Research 2019 15:307

    Content type: Case Report

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  28. Cervical vertebral stenotic myelopathy (CVSM) remains one of the most important abnormalities of the cervical spine resulting in neurological deficits in horses. The aim of the following study was to compare t...

    Authors: Magdalena Szklarz, Anna Lipinska, Malwina Slowikowska, Artur Niedzwiedz, Krzysztof Marycz and Maciej Janeczek

    Citation: BMC Veterinary Research 2019 15:296

    Content type: Case Report

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  29. During skull ontogenesis, growth centers in the skull base and calvarial bones allow gradual expansion of the cranial vault. Premature growth termination of cranial base synchondroses and/or calvarial sutures ...

    Authors: Daniela Farke, Carsten Staszyk, Klaus Failing, Robert M. Kirberger and Martin J. Schmidt

    Citation: BMC Veterinary Research 2019 15:221

    Content type: Research article

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  30. Degenerative myelopathy (DM) is a progressive neurodegenerative disease frequently found in Pembroke Welsh Corgis (PWCs). Most DM-affected PWCs are homozygous for the mutant superoxide dismutase 1 (SOD1) allele; ...

    Authors: Kohei Nakata, Kazuki Heishima, Hiroki Sakai, Osamu Yamato, Yu Furusawa, Hidetaka Nishida, Sadatoshi Maeda and Hiroaki Kamishina

    Citation: BMC Veterinary Research 2019 15:192

    Content type: Research article

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  31. A retrospective case series study was undertaken to describe the magnetic resonance imaging (MRI) findings in Pug dogs with thoracolumbar myelopathy and concurrent caudal articular process (CAP) dysplasia. Ele...

    Authors: Colin J. Driver, Jeremy Rose, Anna Tauro, Ricardo Fernandes and Clare Rusbridge

    Citation: BMC Veterinary Research 2019 15:182

    Content type: Research article

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  32. Mutations in the N-myc downstream-regulated gene 1 (NDRG1) can cause degenerative polyneuropathy in humans, dogs, and rodents. In humans, this motor and sensory neuropathy is known as Charcot-Marie-Tooth disease ...

    Authors: Fredrik S. Skedsmo, Michael A. Tranulis, Arild Espenes, Kristian Prydz, Kaspar Matiasek, Gjermund Gunnes, Lene C. Hermansen and Karin H. Jäderlund

    Citation: BMC Veterinary Research 2019 15:121

    Content type: Research article

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  33. Polymelia is a congenital defect characterized by one or more supernumerary legs. The genetics and aetiology of this condition in cattle have not yet been thoroughly investigated even though several case repor...

    Authors: Ute Morath-Huss, Cord Drögemüller, Michael Stoffel, Christina Precht, Patrik Zanolari and Claudia Spadavecchia

    Citation: BMC Veterinary Research 2019 15:102

    Content type: Case Report

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  34. Osseous- associated cervical spondylomyelopathy (OA-CSM) has a high prevalence in Great Danes. In order to understand the progression of osseous changes, we aimed to perform a long-term computed tomographic (C...

    Authors: Daniella Vansteenkiste, Paula Martin-Vaquero, Marília Bonelli, Luciana B. da Costa and Ronaldo C. da Costa

    Citation: BMC Veterinary Research 2019 15:90

    Content type: Research article

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  35. β-amyloid (Aβ) can accumulate in the brain of aged dogs, and within vessels walls, the disease is called cerebral amyloid angiopathy (CAA). In humans, Alzheimer’s disease and CAA are strongly correlated with c...

    Authors: Laís Limeira Rodrigues, Leonardo Pereira Mesquita, Rafael Carneiro Costa, Raquel Gonçalves Gomes, Daniel Arrais Biihrer and Paulo César Maiorka

    Citation: BMC Veterinary Research 2018 14:370

    Content type: Case Report

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  36. Paralytic form of rabies is frequent in cattle in Latin America, but it is uncommon in goats. There are few clinical reports on furious rabies affecting goats, and the sporadic cases of rabid goats from survei...

    Authors: Igor Louzada Moreira, Davi Emanuel Ribeiro de Sousa, Jair Alves Ferreira-Junior, Márcio Botelho de Castro, Tayná Cardim Morais Fino, José Renato Junqueira Borges, Benito Soto-Blanco and Antonio Carlos Lopes Câmara

    Citation: BMC Veterinary Research 2018 14:338

    Content type: Case report

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  37. Distinguishing between meningeal-based and intra-axial lesions by means of magnetic resonance (MR) imaging findings may occasionally be challenging. Meningiomas and gliomas account for most of the total primar...

    Authors: Tommaso Banzato, Marco Bernardini, Giunio B. Cherubini and Alessandro Zotti

    Citation: BMC Veterinary Research 2018 14:317

    Content type: Methodology article

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  38. When surgical treatment of cervical vertebral malformation is considered, precise localization of compression sites is essential, but remains challenging. Magnetic motor evoked potentials (mMEP) from paraverte...

    Authors: Joke Rijckaert, Bart Pardon, Luc Van Ham, Philip Joosten, Gunther van Loon and Piet Deprez

    Citation: BMC Veterinary Research 2018 14:290

    Content type: Methodology article

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  39. Incubation period, disease progression, pathology and clinical presentation of classical scrapie in sheep are highly dependent on PRNP genotype, time and route of inoculation and prion strain. Our experimental mo...

    Authors: Siv Meling, Kerstin Skovgaard, Kjetil Bårdsen, Peter Mikael Helweg Heegaard and Martha J. Ulvund

    Citation: BMC Veterinary Research 2018 14:281

    Content type: Research article

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  40. Levetiracetam can be used for seizure control alone or in combination with other antiepileptic medications. A previous study achieved the minimum targeted serum drug concentration after rectal administration o...

    Authors: Giulia Cagnotti, Rosangela Odore, Giulia Gardini, Stefano Amedeo, Iride Bertone, Giulia Guerriero, Laura Lentini, Elena Dappiano and Antonio D’Angelo

    Citation: BMC Veterinary Research 2018 14:189

    Content type: Research article

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  41. The enteric nervous system (ENS), located in the intestinal wall and characterized by considerable independence from the central nervous system, consists of millions of cells. Enteric neurons control the major...

    Authors: Slawomir Gonkowski, Krystyna Makowska and Jaroslaw Calka

    Citation: BMC Veterinary Research 2018 14:169

    Content type: Research article

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  42. Hydrocephalus is a multifactorial condition, whose aetiology is not fully understood. Congenital hydrocephalus frequently occurs in small and brachycephalic dog breeds. Although it is widely accepted that the ...

    Authors: Wojciech Sokołowski, Norbert Czubaj, Michał Skibniewski, Karolina Barszcz, Marta Kupczyńska, Wojciech Kinda and Zdzisław Kiełbowicz

    Citation: BMC Veterinary Research 2018 14:162

    Content type: Research article

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  43. There are indications that transcranial electrical stimulation (TES) assesses the motor function of the spinal cord in horses in a more sensitive and reproducible fashion than transcranial magnetic stimulation...

    Authors: Sanne Lotte Journée, Henricus Louis Journée, Cornelis Marinus de Bruijn and Cathérine John Ghislaine Delesalle

    Citation: BMC Veterinary Research 2018 14:121

    Content type: Research article

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  44. Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiar...

    Authors: Srdjan Cirovic, Robert Lloyd, Jelena Jovanovik, Holger A. Volk and Clare Rusbridge

    Citation: BMC Veterinary Research 2018 14:82

    Content type: Research article

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  45. The Rocky Mountain elk (Cervus elaphus nelsoni) prion protein gene (PRNP) is polymorphic at codon 132, with leucine (L132) and methionine (M132) allelic variants present in the population. In elk experimentally i...

    Authors: S. Jo Moore, Catherine E. Vrentas, Soyoun Hwang, M. Heather West Greenlee, Eric M. Nicholson and Justin J. Greenlee

    Citation: BMC Veterinary Research 2018 14:80

    Content type: Research article

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  46. Understanding the efficacy and safety profile of antiepileptic drugs (AEDs) in feline epilepsy is a crucial consideration for managing this important brain disease. However, there is a lack of information abou...

    Authors: Marios Charalambous, Akos Pakozdy, Sofie F. M. Bhatti and Holger A. Volk

    Citation: BMC Veterinary Research 2018 14:64

    Content type: Research article

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  47. In birds there are reports of intracranial lesions but not of the clinical, computed tomographic and histopathologic features of acute intraparenchymal cerebral haemorrhage in Iberian golden eagle.

    Authors: Cláudia S. Baptista, Carla Monteiro, Hélder Fernandes, Ana Canadas, Luísa Guardão and Joana C. Santos

    Citation: BMC Veterinary Research 2018 14:60

    Content type: Case Report

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