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Fig. 1 | BMC Veterinary Research

Fig. 1

From: Local assessment of the immunohistochemical expression of Foxp3+ regulatory T lymphocytes in the different pathological forms associated with bovine paratuberculosis

Fig. 1

Photomicrographs of jejunal tissue samples showing immunolabelling for Foxp3+ T cells, from control (a-b) and infected animals (c-h) showing different types of lesions associated with Map infection. (a-b). Positively immunolabelled cells show a bright brown stain in their cytoplasm. Control (C) animals with low presence of Foxp3+ T cells both in gut-associated lymphoid tissue (GALT) (a) and intestinal mucosa (MUCOSA) (b). (c-d) Animals with focal (F) lesions with a pronounced increase of immunolabelled Foxp3+ T lymphocytes is observed in the GALT (c) and to a lesser extent in the lamina propria (d). (e-f) Diffuse paucibacillary (PB) lesions where Foxp3+ T lymphocytes are also seen among the lymphocytic infiltrate of the LP (f) and in higher numbers on the GALT (e). (g-h) Diffuse multibacillary (MB) lesions with reduced presence of Foxp3+ T cells either in the GALT (g) or among the granulomas of the lamina propria (h), in similar amounts that the control (C) group. No specific distribution patter of the Foxp3+ T cells were detected in relation with the granulomas in any intestinal areas analyzed. Scale bar = 200 μm. Harris´s haematoxylin counterstain. e: epithelium lining the intestinal mucosa; lp: lamina propria; g: intestinal glands.

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BMC Veterinary Research

ISSN: 1746-6148

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