First report of Serotype-1 Marek’s disease virus (MDV-1) with oncogenic form in backyard turkeys in Turkey: a molecular analysis study

Table 2 Amino acid substitutions in MEQ oncoprotein of the Turkish strains and the reference strains

(Pathotypes) Strain/isolates	Basic region		Leucine Zipper					Repression/Transactivation domain
(Pathotypes) Strain/isolates	77	80	88	93	110	115	119	139	153 PPPP	176 PPPP	180	217	218 PPPP	277	283	315	320
MDV-1/TR-21/turkey	E	Y	A	Q	S	V	C	T	P	P	T	P	S	L	A	W	I
(v)MD70/13	K	D	.	.	C	.	.	.	.	.	.	.	P	.	.	S	.
(v)617A	.	.	.	.	C	.	R	.	.	.	.	A	P	.	.	S	.
(vv)Md5	K	D	.	.	C	.	.	.	.	.	.	A	P	.	V	S	T
(vv)RB1B	K	D	.	.	C	.	.	.	.	.	.	.	P	.	.	S	.
(vv+)648A	K	D	.	.	C	.	R	.	Q	A	A	A	P	P	.	S	.
(vv+)New	K	D	.	.	C	.	R	.	Q	A	.	A	P	.	V	S	T
(vv+)W	K	D	.	.	C	.	.	.	.	.	.	A	P	.	V	S	T
(vv+)ATE2539	.	.	T	R	C	.	.	A	.	.	.	.	P	.	.	S	.
(vv+)Polen5	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	.
GaHV-2/Italy/Ck/625/16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	.
Layer-GaHV-2-02-TR-2017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	–	–
MDV/Tur/2019	.	.	T	R	C	L	.	A	.	.	.	.	P	.	.	S	.
TrMDV1/19	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	N
GaHV-2/Italy/Turkey/601/16	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	S	.

Pathotypes of virulent MDV; vMDV, very virulent MDV; vvMDV, very virulent plus MDV; vv + MDV
“.” mean same to the consensus amino acids below corresponding sites
“-” mean lacking of consensus amino acids below corresponding sites

ISSN: 1746-6148