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Fig. 5 | BMC Veterinary Research

Fig. 5

From: Use of immune repertoire sequencing to resolve discordant microscopic and immunochemical findings in a case of T cell-rich large B cell lymphoma in a young dog

Fig. 5

Lymphoma, liver, dog. a The hepatic parenchyma is effaced by aggregates of large lymphocytes surrounded by numerous small lymphocytes. HE, 400x magnification. b Higher magnification of field in Fig. 4a. Large lymphocytes have stippled chromatin whilst the smaller lymphocytes have dark, condensed chromatin. HE, 1000x magnification. c The small lymphocytes surrounding large aggregated lymphocytes had cytoplasmic immunopositivity (pink) for CD3, but large lymphocytes were negative. Immunohistochemistry (IHC) for CD3, 200x magnification. d The large aggregated lymphocytes had cytoplasmic immunopositivity for CD 79a (brown), but not the surrounding small lymphocytes. IHC for CD79a, 200x magnification

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