Table 2 Calculated cut-off values for fasting indices based on receiver operating characteristic curve and Youden’s index analyses using the euglycemic hyperinsulinemic clamp (M index) as the reference for diagnosing insulin resistance
From: Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses
Variable | Cut-off values to predict IR | AUC | Sn% (95 % CI) | Sp% (95 % CI |
|---|---|---|---|---|
Insulin sensitivity: | ||||
1/Insulin (mL/µIU) | < 0.11 | 0.94 (0.88–0.99) | 91 (77–97) | 85 (66–94) |
RISQI ([µIU/ml]−0.5) | < 0.32 | 0.94 (0.88–0.99) | 91 (77–97) | 85 (66–94) |
QUICKI | < 0.33 | 0.93 (0.87–0.99) | 85 (70–94) | 85 (67–94) |
β-cell response: | ||||
FI (µIU/mL) | > 9.5 | 0.94 (0.88–0.99) | 91 (77–97) | 85 (66–94) |
MIRG ([µIUins]2 /[10•L• mggluc]) | > 4.4 | 0.93 (0.87–0.99) | 88 (73–95) | 85 (66–93) |
HOMA-β | > 147 | 0.94 (0.88–0.99) | 79 (63–90) | 96 (81–100) |