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Table 2 Calculated cut-off values for fasting indices based on receiver operating characteristic curve and Youden’s index analyses using the euglycemic hyperinsulinemic clamp (M index) as the reference for diagnosing insulin resistance

From: Evaluation of fasting plasma insulin and proxy measurements to assess insulin sensitivity in horses

Variable Cut-off values to predict IR AUC Sn% (95 % CI) Sp% (95 % CI
Insulin sensitivity:
 1/Insulin (mL/µIU) < 0.11 0.94 (0.88–0.99) 91 (77–97) 85 (66–94)
 RISQI ([µIU/ml]−0.5) < 0.32 0.94 (0.88–0.99) 91 (77–97) 85 (66–94)
 QUICKI < 0.33 0.93 (0.87–0.99) 85 (70–94) 85 (67–94)
β-cell response:
 FI (µIU/mL) > 9.5 0.94 (0.88–0.99) 91 (77–97) 85 (66–94)
 MIRG ([µIUins]2 /[10•L• mggluc]) > 4.4 0.93 (0.87–0.99) 88 (73–95) 85 (66–93)
 HOMA-β > 147 0.94 (0.88–0.99) 79 (63–90) 96 (81–100)
  1. RISQI reciprocal of the square root of insulin; QUICKI quantitative insulin sensitivity check index; FI fasting insulin concentration; MIRG modified insulin-to-glucose ration; HOMA-β homeostatic model assessment of β-cell function; AUC area under the curve; Sn sensitivity; Sp specificity; CI confidence interval
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