Fig. 4From: Clinical response to isotretinoin and interferon-α of two dogs with cutaneous epitheliotropic T-cell lymphoma: a case reportHistopathology of nodules of dorsum and trunk of case 2. Epidermal and dermal infiltration of lymphoid cells with large nuclei and high mitotic activity (red arrows) are shown in A & B (a: bar = 100 μm, b: bar = 50 μm; H&E stain). The tropism of neoplastic lymphocytes in the epidermis was observed, diagnosed as mycosis fungoides. Immunohistochemistry for CD3 (C & D) reveals infiltration of highly CD3-positive neoplastic lymphocytes in the epidermis and dermis (c: bar = 500 μm, d: bar = 100 μm)Back to article page