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Table 5 The result of the sigmoid Emax model

From: Pharmacokinetic-pharmacodynamic modeling of tylosin against Streptococcus suis in pigs

Parameter

Healthy

porcine streptococcosis

E max

3.230

3.345

EC50

11.171

12.233

E0

−3.488

−3.620

N

1.707

1.849

Emax-E0

6.718

6.965

AUC24 h/MIC for bacteriostatic action

10.679

11.736

AUC24 h/MIC for bactericidal action

49.665

43.032

  1. Emax is maximam difference in log10 of bacterial number of sample incubated with drug, EC50 is the PK-PD parameter of drug that produce 50% of the maximal antibacterial effect, E0 is the difference after 24 h incubation in log10 of number of bacteria in control samples, N is the HILL coefficient which discribes the steepness of the parameter-effect curve
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BMC Veterinary Research

ISSN: 1746-6148

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