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Table 5 Description of chemotherapy protocols based on Chlorambucil (PO) and Prednisolone (PO) administration in low-grade alimentary lymphoma (LGAL) [20, 59, 72, 97]

From: Feline low-grade alimentary lymphoma: an emerging entity and a potential animal model for human disease

Study

Stein et al. [97]

Lingard et al. [59]

Kiselow et al. [72]

Fondacaro et al. [20]

Number of cases

28

12

41

29

Prednisolone

1–2 mg/kg PO q24hb

3 mg/kg PO q24h, tapering to 1–2 mg/kg once in remission

5 mg/cat PO q12-24 h

10 mg/cat PO/cat/day

Chlorambucil

20 mg/m2 PO q2wkc

15 mg/m2 PO q24h for 4d q3wk

2 mg/cat PO q48h

15 mg/m2 PO q24h for 4d q3wkd

Number responding

27 (96%)

NA

37 (95%)

NA

Complete remission rate

NA

NA

22 (56%)

20 (69%)

Median remission timea

786 days

505 days

897 days

615 days

Median survival time

NA

513 days

704 days

510 days

  1. NA not available
  2. aRemission time in days for cats displaying a complete response; bTwo cats received dexamethasone, initially at immunosuppressive dosages and then at dosages that were gradually tapered over the course of 3 weeks; cBecause of client preference, two cats were switched to 20 mg/m2 chlorambucil orally q3wk; dTwelve of the 20 cats that achieved CR received cyclophosphamide 225 mg/m2 PO q3wk, once they were out of remission