Fig. 7

Heat map of predicted activation or inhibition of significant pathways from Ingenuity Pathway Analysis that were significantly (−log(p value) > 1.3) enriched and that had a Z-score > |1| for the effect of treatment within each genetic line and for the interaction effect between line and treatment for each time point. Complete names of the pathways show the predicted activation of the pathway (Z-score > 1) or inhibition of the pathways (Z-score < − 1). Predicted Z-score for the interaction effect identify pathways primarily enriched in Fayoumi (Z-score > 1) or Leghorn (Z-score < − 1)