Table 6 Mean (CV%) pharmacokinetic parameters by group for robenacoxib administered orally once daily for 6 months at 3 dose levels
Group (Dose) | Day | Cmax (ng/mL) | AUClast (h x ng/mL) | Tmax (h) |
|---|---|---|---|---|
2 (2 mg/kg) | 1 | 1888 (55) | 2091 (23) | 1.03 (64) |
30 | 1384 (51) | 2042 (32) | 1.06 (58) | |
150 | 5277 (45) | 6629 (45) | 0.94 (19) | |
3 (6 mg/kg) | 1 | 4255 (51) | 8626 (53) | 1.28 (63) |
30 | 5940 (55) | 9700 (24) | 1.13 (51) | |
150 | 4146 (64) | 7602 (44) | 0.81 (32) | |
4 (10 mg/kg) | 1 | 6612 (44) | 15,246 (35) | 1.88 (19) |
30 | 5877 (39) | 13,803 (22) | 1.25 (52) | |
150 | 4777 (36) | 11,077 (32) | 1.25 (52) |