Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis

Table 2 Magnetic resonance imaging (MRI) scores (Mean ± SD) for each group (control, MSC-naïve, MSC-primed)

MRI grading parameter	Two months end-point (Phase 2 carpi)			Six months end-point (Phase 1 carpi)
MRI grading parameter	Control n = 4	MSC-naïve n = 7	MSC-primed n = 7	Control n = 4	MSC-naïve n = 7	MSC-primed n = 7
Osteophyte formation	0.25 ± 0.50	0.00 ± 0.00	0.00 ± 0.00	0.00 ± 0.00	0.33 ± 0.58	0.00 ± 0.00
Synovial effusion	1.50 ± 0.58^a,b	0.67 ± 0.58^a,c	2.25 ± 0.50^b	1.25 ± 0.50	1.33 ± 0.58	1.75 ± 0.96
Osseous edema	0.25 ± 0.50	0.33 ± 0.58	1.25 ± 1.26	0.00 ± 0.00	0.00 ± 0.00	0.25 ± 0.50
Subchondral bone damage	1.00 ± 0.00	0.33 ± 0.58	0.50 ± 0.58	0.25 ± 0.50	0.33 ± 0.58	0.75 ± 0.50

Scores are shown for each MRI grading parameter in each group at each assessed end-point (six and two months, phases 1 and 2). The number (n) of radio-carpal (RC) joints assessed in each group at each end-point is showed in the table. Higher scores mean higher severity of the MRI findings, 4 being the highest possible score for each parameter. Different letters mean statistically significant differences (p < 0.05). Note that significant differences were only found between groups for the parameter synovial effusion at two months (phase 2), but not for other parameters or between two and six months

ISSN: 1746-6148