Skip to main content
Fig. 2 | BMC Veterinary Research

Fig. 2

From: Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritis

Fig. 2

Synovial fluid (SF) assessment included total protein, haptoglobin, and total and differential white cells counts. The two-phase study design aimed to perform paired comparison between two and six months’ end-points but not along the study because both phase 1 and phase 2 carpi underwent the same procedure. Thus, data collected from phase 1 and phase 2 carpi was used for analyses until two months. Therefore, number of radio-carpal (RC)-joints assessed for synovial parameters were n = 36 until two months (8 RC-joints control, 14 RC-joints MSC-naïve, 14 RC-joints MSC-primed), and n = 18 for six months (4 RC-joints control, 7 RC-joints MSC-naïve, 7 RC-joints MSC-primed). Light grey lines and symbols represent control group, dark grey lines and symbols represent MSC-naïve group and black lines and symbols represent MSC-primed group. Results are presented as Mean ± SEM of each parameter at the evaluated time-points. Significant differences are shown between time-points within each group: time-points from Time 0 (pre-lesion) to Week 5 (just before second injection) were compared to the time of the first injection (Week 2). Subsequent time-points were compared to second injection (Week 5). a Evolution of the SF total protein (g/dl). b Evolution of the haptoglobin concentration (mg/ml) in SF and serum along the study. Continuous lines represent SF values and discontinuous lines represent serum values (control, n = 4 animals; MSC-naïve, n = 7 animals; MSC-primed, n = 7 animals). Asterisks (*) are used for significant differences in SF and hashes (#) are used for significant differences in serum. c Evolution of the SF total white cells count (cells/μL) along the study. d Evolution of the percentage (%) of neutrophils in SF along the study. (* = p < 0.05, ** = p < 0.01, *** = p < 0.001; # = p < 0.05, ## = p < 0.01, ### = p < 0.001)

Back to article page