Fig. 2From: Assessment of effectiveness and safety of repeat administration of proinflammatory primed allogeneic mesenchymal stem cells in an equine model of chemically induced osteoarthritisSynovial fluid (SF) assessment included total protein, haptoglobin, and total and differential white cells counts. The two-phase study design aimed to perform paired comparison between two and six months’ end-points but not along the study because both phase 1 and phase 2 carpi underwent the same procedure. Thus, data collected from phase 1 and phase 2 carpi was used for analyses until two months. Therefore, number of radio-carpal (RC)-joints assessed for synovial parameters were n = 36 until two months (8 RC-joints control, 14 RC-joints MSC-naïve, 14 RC-joints MSC-primed), and n = 18 for six months (4 RC-joints control, 7 RC-joints MSC-naïve, 7 RC-joints MSC-primed). Light grey lines and symbols represent control group, dark grey lines and symbols represent MSC-naïve group and black lines and symbols represent MSC-primed group. Results are presented as Mean ± SEM of each parameter at the evaluated time-points. Significant differences are shown between time-points within each group: time-points from Time 0 (pre-lesion) to Week 5 (just before second injection) were compared to the time of the first injection (Week 2). Subsequent time-points were compared to second injection (Week 5). a Evolution of the SF total protein (g/dl). b Evolution of the haptoglobin concentration (mg/ml) in SF and serum along the study. Continuous lines represent SF values and discontinuous lines represent serum values (control, n = 4 animals; MSC-naïve, n = 7 animals; MSC-primed, n = 7 animals). Asterisks (*) are used for significant differences in SF and hashes (#) are used for significant differences in serum. c Evolution of the SF total white cells count (cells/μL) along the study. d Evolution of the percentage (%) of neutrophils in SF along the study. (* = p < 0.05, ** = p < 0.01, *** = p < 0.001; # = p < 0.05, ## = p < 0.01, ### = p < 0.001)Back to article page