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Table 1 Characteristics of different groups of dogs infected with Leishmania infantum based on their APP response

From: Use of acute phase proteins for the clinical assessment and management of canine leishmaniosis: general recommendations

 

Characteristics

Types of dog that fit each category

Correspondence with guidelines

CRP and ferritin

Clinical signs at physical exam

 

LeishVet

CLWG

Group 1

In reference range

No

Infected but resistant to the development of clinical leishmaniosis.

Dogs that have responded to treatment.

Infected but no APR yet developed.

Not applicable

Stage A (exposed)

Stage B (infected)

Group 2

Moderate increase in one or both of them

No

Expected to exhibit clinical signs in the future.

Have other conditions that increase APPs (infections, neoplasms or trauma).

Not applicable

Stage A (exposed)

Stage B (infected)

Stage C (sick dogs)

Group 3(a)

Moderate increase in one or both of them

Yes

Dogs with clinical leishmaniosis (mild to moderate disease).

Stages I and II (mild to moderate disease)

Stage C (sick dogs)

Group 3(b)

Major increase in one or both of them

Yes

Dogs with severe clinical leishmaniosis with immunomediated complications.

Stages III and IV (severe to very severe disease)

Stage D (severely sick dogs)