Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

Table 5 Mean ± SD of tCr concentrations (mmol L-1 of brain water)

			Dose 1	Dose 2	Dose 3	Arithmetic mean
			Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
tCr	BG	Isoflurane	5.857 ± 0.647	6.154 ± 0.400	5.699 ± 0.657	5.925 ± 0.498¹
		Sevoflurane	6.038 ± 0.486^A	6.371 ± 0.338^B	6.249 ± 0.353^AB	6.219 ± 0.344¹²
		Propofol	5.958 ± 0.230	6.043 ± 0.496	6.011 ± 0.451	6.026 ± 0.328¹²
		Alfaxalone	6.320 ± 0.218	6.310 ± 0.439	6.446 ± 0.429	6.359 ± 0.283²
	PL	Isoflurane	5.419 ± 0.180	5.598 ± 0.303	5.607 ± 0.210	5.556 ± 0.200
		Sevoflurane	5.441 ± 0.460	5.580 ± 0.383	5.584 ± 0.304	5.535 ± 0.347
		Propofol	5.627 ± 0.312	5.531 ± 0.407	5.494 ± 0.394	5.576 ± 0.342
		Alfaxalone	5.439 ± 0.350	5.420 ± 0.358	5.402 ± 0.491	5.420 ± 0.376
	OL	Isoflurane	6.647 ± 0.482	6.825 ± 0.371	6.496 ± 0.758	6.566 ± 0.527
		Sevoflurane	6.734 ± 0.176	6.831 ± 0.319	6.809 ± 0.403	6.792 ± 0.250
		Propofol	6.783 ± 0.321	6.624 ± 0.456	6.862 ± 0.355	6.670 ± 0.487
		Alfaxalone	6.761 ± 0.268	6.718 ± 0.249	6.588 ± 0.559	6.689 ± 0.325

Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic different numerical superscripts differ significantly between arithmetic mean tCr concentrations of each anesthetic

ISSN: 1746-6148