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Table 1 Mean ± SD of Glx concentrations (mmol L-1 of brain water) and Glx/tCr ratios

From: Effects of isoflurane, sevoflurane, propofol and alfaxalone on brain metabolism in dogs assessed by proton magnetic resonance spectroscopy (1H MRS)

 

Dose 1

Dose 2

Dose 3

Arithmetic mean

Mean ± SD

Mean ± SD

Mean ± SD

Mean ± SD

GLX

BG

Isoflurane

13.568 Â± 1.196

13.017 Â± 1.037

13.039 Â± 1.703

13.146 Â± 1.003

Sevoflurane

12.532 Â± 1.369

12.931 Â± 1.156

13.226 Â± 1.266

12.896 Â± 1.005

Propofol

12.388 Â± 1.066

12.730 Â± 1.191

12.839 Â± 1.582

12.760 Â± 1.105

Alfaxalone

12.941 Â± 1.353

13.133 Â± 1.670

13.423 Â± 1.756

13.166 Â± 1.233

PL

Isoflurane

11.831 Â± 2.167AB

13.119 Â± 1.695A

11.821 Â± 1.911B

12.345 Â± 1.6741

Sevoflurane

11.189 Â± 1.375

10.632 Â± 1.301

10.767 Â± 0.888

10.863 Â± 0.99712

Propofol

10.201 Â± 1.818

10.165 Â± 1.669

10.481 Â± 2.286

10.295 Â± 1.7222

Alfaxalone

10.087 Â± 2.052

10.766 Â± 2.084

10.315 Â± 1.418

10.390 Â± 1.3532

OL

Isoflurane

12.957 Â± 1.341

12.263 Â± 1.648

13.083 Â± 1.845

12.913 Â± 1.463

Sevoflurane

12.869 Â± 2.277

12.311 Â± 1.752

12.700 Â± 1.539

12.627 Â± 1.694

Propofol

12.043 Â± 0.400

12.135 Â± 0.809

12.587 Â± 1.289

12.223 Â± 0.646

Alfaxalone

12.555 Â± 1.586

12.320 Â± 1.075

12.609 Â± 1.055

12.495 Â± 1.032

GLX/tCr

BG

Isoflurane

2.326 Â± 0.136

2.118 Â± 0.144

2.215 Â± 0.416

2.196 Â± 0.214

Sevoflurane

2.082 Â± 0.221

2.032 Â± 0.185

2.117 Â± 0.180

2.077 Â± 0.127

Propofol

2.082 Â± 0.199

2.109 Â± 0.153

2.136 Â± 0.216

2.119 Â± 0.141

Alfaxalone

2.045 Â± 0.182

2.082 Â± 0.232

2.091 Â± 0.290

2.073 Â± 0.175

PL

Isoflurane

2.177 Â± 0.365

2.353 Â± 0.352

2.110 Â± 0.342

2.224 Â± 0.306

Sevoflurane

2.064 Â± 0.265

1.908 Â± 0.240

1.932 Â± 0.178

1.968 Â± 0.197

Propofol

1.826 Â± 0.385

1.858 Â± 0.388

1.931 Â± 0.516

1.865 Â± 0.396

Alfaxalone

1.857 Â± 0.365

2.001 Â± 0.451

1.915 Â± 0.242

1.924 Â± 0.272

OL

Isoflurane

1.964 Â± 0.302

1.800 Â± 0.243

2.028 Â± 0.278

1.984 Â± 0.287

Sevoflurane

1.914 Â± 0.353

1.810 Â± 0.300

1.870 Â± 0.240

1.864 Â± 0.282

Propofol

1.777 Â± 0.063

1.838 Â± 0.147

1.834 Â± 0.156

1.839 Â± 0.131

Alfaxalone

1.868 Â± 0.280

1.839 Â± 0.213

1.922 Â± 0.193

1.877 Â± 0.220

  1. Mean ± SD for the three different doses and the arithmetic mean of the three doses for isoflurane, sevoflurane, propofol and alfaxalone in basal ganglia (BG), parietal lobe (PL) and occipital lobe (OL). Different alphabetical superscripts differ significantly (p < 0.05) between different doses of each anesthetic and different numerical superscripts differ significantly between arithmetic mean Glx concentrations of each anesthetic. For treatment I and S: Dose 1 ≙ time 3; Dose 2 ≙ time 1; Dose 3 ≙ time 2