Fig. 1

Schematic timeline for propofol and alfaxalone (a) and isoflurane and sevoflurane (b) The 30 min equilibration phase was followed by a measurement period of approximately 30 min where a total of three measurements were performed (BG, PL and OL). For treatment I and S the end expiratory concentration had to be adjusted before each equilibration phase. Jugular venous blood samples were taken for serum glucose, lactate and plasma concentrations of propofol and alfaxalone