An optimized swine dysentery murine model to characterize shedding and clinical disease associated with “Brachyspira hampsonii” infection

Table 1 Summarized pathologic lesion results from Experiment 1 evaluating Brachyspira spp. and diet^a in CF-1 mice

				Colon		Caecum
Species Group	Diet	Presence of soft mucoid faeces	Mean faecal consistency score^b	Catarrhal inflammation	Epithelial regeneration	Catarrhal inflammation	Epithelial regeneration
Ctrl	RMH	0/4	0.034	1/4	0/4	0/4	0/4
Ctrl	TD	0/4	0.210	0/4	0/4	0/4	0/4
Bhamp	RMH	0/4	0.161	0/4	0/4	0/4	0/4
Bhamp	TD	4/4	0.823	1/4	0/4	1/4	2/4
Bhyo	RMH	2/4	0.272	2/4	0/4	0/4	0/4
Bhyo	TD	4/4	0.867	2/4	0/4	0/4	2/4

Legend: Ctrl non-inoculated group, Bhamp “B. hampsonii” inoculated group, Bhyo B. hyodysenteriae inoculated group, RMH RMH3000 chow diet (normal zinc), TD TD85420 diet. See Additional files 1, 2, 3, 4 and 5 for description of histopathologic lesion scores
^aValues indicate the numbers (proportions) of mice with each type of clinical sign or lesion
^bMean fecal consistency score calculated by averaging twice daily observations from 3 dpi to termination. Mean fecal score differs across species: Bhyo vs Ctrl (P = 0.007); Bhamp vs Ctrl (P = 0.06). Mean fecal score differs by diet (TD vs RMH): P = 0.02 for Bhyo and Bhamp, P = 0.04 for Ctrl

ISSN: 1746-6148