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Fig. 4 | BMC Veterinary Research

Fig. 4

From: An optimized swine dysentery murine model to characterize shedding and clinical disease associated with “Brachyspira hampsonii” infection

Fig. 4

Cluster dendrogram and data table for Experiment 2 showing clustering of histopathology. Five clusters (Ward’s linkage of rank-scaled scores, Euclidean dissimilarity measure) are evident; unrelated to mouse strain, but associated with clinical outcome. Values in lesion columns represent the lesion severity score of colonic and caecal tissue sections, with more intense grey scale indicating mice with more prevalent lesions. The single mice in cluster 3 (blue) and 4 (orange) had the highest mean faecal scores and most severe colonic and caecal lesions. One inoculated mouse in cluster 2 (red) also had severe intestinal pathology and high faecal score. Cluster 5 (purple) included mice with severe pathology but both had low mean faecal scores. Mice with the least severe clinical disease and pathology were grouped in cluster 1 (green). Clusters R = regeneration of epithelium; NI = neutrophilic inflammation; IM = increased mucoid exudate; CI = catarrhal inflammation; CF1 = CF-1 mouse strain; C3H = C3H mouse strain; Spp. = Brachyspira species used for inoculation; hamp = “B. hampsonii”; ctrl = non-inoculated control; ID = mouse identification; + = soft mucoid faeces present; − = soft mucoid faeces absent

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