Oral treatment | Intramuscular treatment | |||
---|---|---|---|---|
40 mg day−1 | 0.5 mg kg−1 day−1 | 40 mg day−1 | 0.5 mg kg−1 day−1 | |
Cmax (μg L−1) | 2.96 ± 1.50 | 7.01 ± 1.52 | 117 ± 25.8 | 156 ± 78.1 |
Tmax (h) | 2.95 ± 0.820 | 3.85 ± 0.909 | 0.168 ± 0.063 | 0.866 ± 0.273 |
AUC0-tinf (h μg L−1) | 26.1 ± 19.1 | 75.5 ± 25.0 | 232 ± 17.5 | 678 ± 11.5 |
ka (h−1) | 0.363 ± 0.099 | 0.307 ± 0.129 | 17.1 ± 11.2 | 1.93 ± 0.395 |
T1/2a (h) | 2.05 ± 0.588 | 2.53 ± 0.854 | 0.064 ± 0.052 | 0.370 ± 0.083 |
kel (h−1) | 0.362 ± 0.091 | 0.245 ± 0.053 | 0.325 ± 0.046 | 0.132 ± 0.092 |
T1/2el (h) | 2.04 ± 0.553 | 2.97 ± 0.728 | 2.16 ± 0.308 | 3.80 ± 0.499 |
Vd/F (L kg−1) | 11.9 ± 4.89 | 30.1 ± 9.98 | 0.503 ± 0.215 | 2.47 ± 1.61 |
Cl/F (L h−1 kg−1) | 4.66 ± 2.68 | 7.15 ± 1.97 | 0.346 ± 0.026 | 0.737 ± 0.012 |