Skip to main content

Table 1 Pharmacokinetic parameters for metoclopramide, ondansetron and maropitant after IV administration

From: Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study

Parameter

Units

Ondansetron

(n = 8)

Maropitant

(n = 8)

Metoclopramide

(n = 7)

Cmax

μg/L

186.8 ± 60.6

247.0 ± 86.2

113.2 ± 22.4

t1/2

h

1.21 ± 0.51

5.62 ± 0.77

0.87 ± 0.17

AUC0-last

μg/L/h

176.4 ± 32.6

705.2 ± 236

111.9 ± 27.2

Cl

L/kg/h

2.90 ± 0.43

1.57 ± 0.53

4.72 ± 1.25

MRT

h

1.15 ± 0.43

6.68 ± 1.30

1.04 ± 0.16

  1. Legend: All results are presented as the arithmetic mean ± SD except t1/2 which is presents as the harmonic mean ± Pseudo SD
Back to article page

BMC Veterinary Research

ISSN: 1746-6148

Contact us