Fig. 5From: Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover studyNegative Hysteresis relationship for Cortisol and arginine vasopressin (AVP) versus nausea-like behaviour (group average, n = 8 dogs) following 18 mg m−2 cisplatin i.v. The time courses of changes in both biomarkers against VAS are indicated by the dotted black arrows (anticlockwise.) AVP rises with VAS scores but persist to high level when the nausea score decreases (hysteresis loop suggesting a time delay), whereas cortisol follows nausea scores changes more closely in timeBack to article page