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Fig. 2 | BMC Veterinary Research

Fig. 2

From: Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study

Fig. 2

a-f Emesis and Nausea behaviour following 18 mg m−2 cisplatin i.v. The number of vomits (a) and area under the curve of nausea behaviour (b) for all 3 anti-emetic drugs compared to placebo. Timecourse of nausea-like behaviour (VAS) following 18 mg m−2 cisplatin i.v. for each treatment groups; placebo (c), ondansetron 0.5 mg kg−1 (d), maropitant 1 mg kg−1 (e), metoclopramide 0.5 mg kg−1 (f). Values presented as mean ± SEM, n = 8 per group, except metoclopramide group where n = 7. Significant decrease of antiemetic treated groups compared to placebo: mixed linear model (**P < 0.01, *** P < 0.001), Significant increase in nausea behaviour between placebo and anti-emetic treated groups: mixed linear model (†P < 0.05). Anti-emetic treated groups compared to placebo; Area under curve and number of vomits, ANOVA (*P < 0.05, ***P < 0.001)

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