Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis

Felten, Sandra; Leutenegger, Christian M.; Balzer, Hans-Joerg; Pantchev, Nikola; Matiasek, Kaspar; Wess, Gerhard; Egberink, Herman; Hartmann, Katrin

doi:10.1186/s12917-017-1147-8

Table 2 Detailed information for cats of the control group

From: Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis

cat	symptoms leading to inclusion	diagnosis	method of confirmation of diagnosis	samples available	result of RT-PCR of effusion samples	result of RT-PCR of serum/plasma samples	detected mutation
1	pleural effusion	bacterial pleuritis	bacterial culture and cytology	effusion	negative	n.d.	n.d.
2	pleural effusion	chronic kidney disease, hypertensive encephalopathy; effusion most likely due to hypervolemia	full post-mortem examination including histopathology	effusion	FIPV	n.d.	M1058L
3	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
4	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
5	ascites	persistent foramen ovale	histopathology	effusion	negative	n.d.	n.d.
6	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
7	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
8	ascites	invasive pancreatic adenocarcinoma	histology of organ samples (obtained post-mortem)	effusion	negative	n.d.	n.d.
9	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
10	pleural effusion	pulmonary adenocarcinoma	full post-mortem examination including histopathology	effusion	negative	n.d.	n.d.
11	pleural effusion	carcinoma	cytology	effusion	negative	n.d.	n.d.
12	ascites	carcinoma	cytology	effusion	negative	n.d.	n.d.
13	pleural effusion	lymphoma	cytology	effusion	negative	n.d.	n.d.
14	ascites	lymphoma	full post-mortem examination including histopathology	effusion and plasma	negative	negative	n.d.
15	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
16	pleural effusion, neurological signs	carcinoma	full post-mortem examination including histopathology	effusion and plasma	negative	negative	n.d.
17	pleural effusion	chronic cardiomyopathy	full post-mortem examination including histopathology	effusion	negative	n.d.	n.d.
18	fever, icterus	cholangiohepatitis	full post-mortem examination including histopathology	plasma	n.d.	negative	n.d.
19	pleural effusion	pulmonary adenocarcinoma	full post-mortem examination including histopathology	effusion	negative	n.d.	n.d.
20	pleural effusion	lymphoma	full post-mortem examination including histopathology	effusion	negative	n.d.	n.d.
21	pleural effusion and ascites	malignant round cell tumor	cytology	effusion	BLD	n.d.	n.d.
22	pleural effusion	lymphoma	cytology	effusion	BLD	n.d.	n.d.
23	pleural effusion	decompensated cardiac disease	echocardiography	effusion	negative	n.d.	n.d.
24	pleural effusion	bacterial pleuritis	bacterial culture and cytology	effusion	negative	n.d.	n.d.
25	ascites	cholangiocarcinoma	full post-mortem examination including histopathology	effusion	negative	n.d.	n.d.

BLD feline coronavirus present, but below limit of detection, FIPV feline infectious peritonitis virus, n.d. not determined, RT-PCR reverse transcriptase polymerase chain reaction

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