Parameter (units) | Broth | Serum | ||
---|---|---|---|---|
Mean | SD (CV%) | Mean | SD (CV%) | |
Log E0 (CFU/mL) | 2.65 | 0.42 | 1.79 | 0.64 |
Log Emax (CFU/mL) | −5.57 | 0.80 | −6.71 | 0.65 |
Log Emax - Log E0 (CFU/mL) | −8.23 | 0.38 | −8.50 | 0.01 |
Gamma | 3.18 | 1.20 | 4.07 | 0.77 |
AUC24h/MIC for bacteriostatic action (h) | 24.8 | 1.79 (7.2) | 32.4 | 5.30 (16.4) |
AUC24h/MIC50(h) | 31.8 | 4.09 (12.9) | 45.6 | 9.45 (20.7) |
AUC24h/MIC for bactericidal action (h) | 42.0 | 4.34 (10.3) | 48.7 | 6.58 (13.5) |
AUC24h/MIC for 4 log10 reduction (h) | 54.0 | 7.04 (13.0) | 55.5 | 6.43 (11.6) |