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Table 2 A. pleuropneumoniae PK/PD modelling of in vitro marbofloxacin time-kill curves (mean, standard deviation, n = 6)

From: Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling

Parameter (units)

Broth

Serum

Mean

SD (CV%)

Mean

SD (CV%)

Log E0 (CFU/mL)

2.65

0.42

1.79

0.64

Log Emax (CFU/mL)

−5.57

0.80

−6.71

0.65

Log Emax - Log E0 (CFU/mL)

−8.23

0.38

−8.50

0.01

Gamma

3.18

1.20

4.07

0.77

AUC24h/MIC for bacteriostatic action (h)

24.8

1.79 (7.2)

32.4

5.30 (16.4)

AUC24h/MIC50(h)

31.8

4.09 (12.9)

45.6

9.45 (20.7)

AUC24h/MIC for bactericidal action (h)

42.0

4.34 (10.3)

48.7

6.58 (13.5)

AUC24h/MIC for 4 log10 reduction (h)

54.0

7.04 (13.0)

55.5

6.43 (11.6)

  1. E0 = difference in number of organisms (CFU/mL) in control sample in absence of drug between time 0 and 24 h; Emax = difference in number of organisms (CFU/mL) in presence of marbofloxacin between time 0 and 24 h; AUC24/MIC50 = concentration producing reduction in count to 50% of the Emax; Gamma = slope of the curve; detection limit = 33 CFU/mL